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dc.contributor.authorHU, Xiaobo
dc.contributor.authorDAWSON, Simon J.
dc.contributor.authorNAGAOKA, Yui
dc.contributor.authorTANATAN, Aya
dc.contributor.authorHUC, Ivan
dc.date.accessioned2020-09-03T07:56:16Z
dc.date.available2020-09-03T07:56:16Z
dc.date.issued2016
dc.identifier.issn0022-3263
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10862
dc.description.abstractEnWe report here a solid phase synthesis methodology that allows the incorporation of alpha-amino acids (X) into quinoline (Q) oligoamide foldamer sequences. Water-soluble hybrid oligoamides based on the XQ(2) trimer repeat motif were shown to adopt helical conformations presenting alpha-amino acid side chains in a predictable linear array on one face of the helix. In contrast, sequences based on the XQ dimer motif expressed less well-defined behavior, most likely due to local conformational variability precluding long-range order. Also presented is a full structural investigation by NMR of a dodecameric XQ(2)-type foldamer containing four different amino acid residues (Lys, Ala, Asp, and Ser).
dc.language.isoen
dc.title.enSolid-Phase Synthesis of Water-Soluble Helically Folded Hybrid alpha-Amino Acid/Quinoline Oligoamides
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.joc.5b02671
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of Organic Chemistry
bordeaux.page1137-1150
bordeaux.volume81
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Organic%20Chemistry&rft.date=2016&rft.volume=81&rft.issue=3&rft.spage=1137-1150&rft.epage=1137-1150&rft.eissn=0022-3263&rft.issn=0022-3263&rft.au=HU,%20Xiaobo&DAWSON,%20Simon%20J.&NAGAOKA,%20Yui&TANATAN,%20Aya&HUC,%20Ivan&rft.genre=article


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