Afficher la notice abrégée

Surface bound VEGF mimicking peptide maintains endothelial cell proliferation in the absence of soluble VEGF in vitro

dc.contributor.authorLE SAUX, Guillaume
dc.contributor.authorPLAWINSKI, Laurent
dc.contributor.authorPARROT, Camila
dc.contributor.authorNLATE, Sylvain
dc.contributor.authorSERVANT, Laurent
dc.contributor.authorTEICHMANN, Martin
IDREF: 120052652
dc.contributor.authorBUFFETEAU, Thierry
dc.contributor.authorDURRIEU, Marie-Christine
dc.date.accessioned2020-09-03T07:56:13Z
dc.date.available2020-09-03T07:56:13Z
dc.date.issued2016
dc.identifier.issn1549-3296
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10848
dc.description.abstractEnContinuous glucose monitoring is an efficient method for the management of diabetes and in limiting the complications induced by large fluctuations in glucose levels. For this, intravascular systems may assist in producing more reliable and accurate devices. However, neovascularization is a key factor to be addressed in improving their biocompatibility. In this scope, the perennial modification of the surface of an implant with the proangiogenic Vascular Endothelial Growth Factor mimic peptide (SVVYGLR peptide sequence) holds great promise. Herein, we report on the preparation of gold substrates presenting the covalently grafted SVVYGLR peptide sequence and their effect on HUVEC behavior. Effective coupling was demonstrated using XPS and PM-IRRAS. The produced surfaces were shown to be beneficial for HUVEC adhesion. Importantly, surface bound SVVYGLR is able to maintain HUVEC proliferation even in the absence of soluble VEGF. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1425-1436, 2016.
dc.language.isoen
dc.title.enSurface bound VEGF mimicking peptide maintains endothelial cell proliferation in the absence of soluble VEGF in vitro
dc.typeArticle de revue
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of Biomedical Materials Research Part A
bordeaux.page1425-1436
bordeaux.volume104
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Biomedical%20Materials%20Research%20Part%20A&rft.date=2016&rft.volume=104&rft.issue=6&rft.spage=1425-1436&rft.epage=1425-1436&rft.eissn=1549-3296&rft.issn=1549-3296&rft.au=LE%20SAUX,%20Guillaume&PLAWINSKI,%20Laurent&PARROT,%20Camila&NLATE,%20Sylvain&SERVANT,%20Laurent&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée