Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State
| dc.contributor.author | MANDAL, Pradeep K. | |
| dc.contributor.author | BAPTISTE, Benoit | |
| dc.contributor.author | D'ESTAINTOT, Beatrice Langlois | |
| dc.contributor.author | KAUFFMANN, Brice | |
| dc.contributor.author | HUC, Ivan | |
| dc.date.accessioned | 2020-09-03T07:56:12Z | |
| dc.date.available | 2020-09-03T07:56:12Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1439-4227 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10843 | |
| dc.description.abstractEn | Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G(4)T(4)G(4))(2) with tetramer 1a helically folded oligo-quinolinecarboxamide bearing cationic side chainsthat is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G(4)T(4)G(4))(2) in the solid state are observed. | |
| dc.language.iso | en | |
| dc.title.en | Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/cbic.201600281 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | ChemBioChem | |
| bordeaux.page | 1911-1914 | |
| bordeaux.volume | 17 | |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
| bordeaux.issue | 20 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ChemBioChem&rft.date=2016&rft.volume=17&rft.issue=20&rft.spage=1911-1914&rft.epage=1911-1914&rft.eissn=1439-4227&rft.issn=1439-4227&rft.au=MANDAL,%20Pradeep%20K.&BAPTISTE,%20Benoit&D'ESTAINTOT,%20Beatrice%20Langlois&KAUFFMANN,%20Brice&HUC,%20Ivan&rft.genre=article |
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