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Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against alpha-Synuclein Aggregation and Cytotoxicity

dc.relation.isnodouble6ddf6c55-c2dd-4884-ac24-1fe7dd5f14fa*
dc.relation.isnodouble722978d2-8240-44b7-ba50-158ae65410cf*
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorTEMSAMANI, Hamza
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDECOSSAS-MENDOZA, Marion
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAMBERT, Olivier
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMERILLON, Jean-Michel
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.date.accessioned2020-09-03T07:56:04Z
dc.date.available2020-09-03T07:56:04Z
dc.date.issued2016
dc.identifier.issn2072-6643
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10811
dc.description.abstractEnThe aggregation of alpha-synuclein is one on the key pathogenic events in Parkinson's disease. In the present study, we investigated the inhibitory capacities of stilbenes against alpha-synuclein aggregation and toxicity. Thioflavin T fluorescence, transmission electronic microscopy, and SDS-PAGE analysis were performed to investigate the inhibitory effects of three stilbenes against alpha-synuclein aggregation: piceatannol, ampelopsin A, and isohopeaphenol. Lipid vesicle permeabilization assays were performed to screen stilbenes for protection against membrane damage induced by aggregated alpha-synuclein. The viability of PC12 cells was examined using an MTT assay to assess the preventive effects of stilbenes against alpha-synuclein-induced toxicity. Piceatannol inhibited the formation of alpha synuclein fibrils and was able to destabilize preformed filaments. It seems to induce the formation of small soluble complexes protecting membranes against alpha-synuclein-induced damage. Finally, piceatannol protected cells against alpha-synuclein-induced toxicity. The oligomers tested (ampelopsin A and hopeaphenol) were less active.
dc.language.isoen
dc.title.enPiceatannol and Other Wine Stilbenes: A Pool of Inhibitors against alpha-Synuclein Aggregation and Cytotoxicity
dc.typeArticle de revue
dc.identifier.doi10.3390/nu8060367
dc.subject.halChimie/Matériaux
bordeaux.journalNutrients
bordeaux.volume8
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionINRAE
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2016&rft.volume=8&rft.issue=6&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=TEMSAMANI,%20Hamza&KRISA,%20Stephanie&DECOSSAS-MENDOZA,%20Marion&LAMBERT,%20Olivier&MERILLON,%20Jean-Michel&rft.genre=article


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