Tip-Enhanced Raman Spectroscopy to Distinguish Toxic Oligomers from Abeta1-42 Fibrils at the Nanometer Scale
| dc.relation.isnodouble | 670fa94d-8a01-48bf-a780-f148a564e128 | * |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | BONHOMMEAU, Sebastien | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | TALAGA, David | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | HUNEL, Julien | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CULLIN, Christophe
ORCID: 0000-0003-4110-4677 IDREF: 85920959 | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LECOMTE, Sophie | |
| dc.date.accessioned | 2020-07-09T14:17:10Z | |
| dc.date.available | 2020-07-09T14:17:10Z | |
| dc.date.issued | 2017-02 | |
| dc.identifier.issn | 1433-7851 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10354 | |
| dc.description.abstractEn | For the first time, natural Abeta1-42 fibrils (WT) implicated in Alzheimer's disease, as well as two synthetic mutants forming less toxic amyloid fibrils (L34T) and highly toxic oligomers (oG37C), are chemically characterized at the scale of a single structure using tip-enhanced Raman spectroscopy (TERS). While the proportion of TERS features associated with amino acid residues is similar for the three peptides, a careful examination of amide I and amide III bands allows us to clearly distinguish WT and L34T fibers organized in parallel beta-sheets from the small and more toxic oG37C oligomers organized in anti-parallel beta-sheets. | |
| dc.title.en | Tip-Enhanced Raman Spectroscopy to Distinguish Toxic Oligomers from Abeta1-42 Fibrils at the Nanometer Scale | |
| dc.title.alternative | Angewandte Chemie (International ed. in English) | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/anie.201610399 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Angew Chem Int Ed Engl | |
| bordeaux.page | 1771-1774 | |
| bordeaux.volume | 56 | |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
| bordeaux.issue | 7 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angew%20Chem%20Int%20Ed%20Engl&rft.date=2017-02&rft.volume=56&rft.issue=7&rft.spage=1771-1774&rft.epage=1771-1774&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=BONHOMMEAU,%20Sebastien&TALAGA,%20David&HUNEL,%20Julien&CULLIN,%20Christophe&LECOMTE,%20Sophie&rft.genre=article |
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