Metal-Coordination-Assisted Folding and Guest Binding in Helical Aromatic Oligoamide Molecular Capsules
dc.relation.isnodouble | 8787c50e-c20a-4284-95e8-7807da1c97d8 | * |
dc.relation.isnodouble | fa9ceb49-1614-4269-9360-66150af18b13 | * |
dc.relation.isnodouble | d3e9affd-c524-4b95-a31c-566d7ca6ec51 | * |
dc.contributor.author | HOREAU, Maxime | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | LAUTRETTE, Guillaume | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | WICHER, Barbara | |
dc.contributor.author | BLOT, Virginie | |
dc.contributor.author | LEBRETON, Jacques | |
dc.contributor.author | PIPELIER, Muriel | |
dc.contributor.author | DUBREUIL, Didier | |
dc.contributor.author | FERRAND, Yann | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | HUC, Ivan | |
dc.date.accessioned | 2020-07-09T14:16:50Z | |
dc.date.available | 2020-07-09T14:16:50Z | |
dc.date.issued | 2017-06-06 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10313 | |
dc.description.abstractEn | The development of foldamer-based receptors is driven by the design of monomers with specific properties. Herein, we introduce a pyridazine-pyridine-pyridazine diacid monomer and its incorporation into helical aromatic oligoamide foldamer containers. This monomer codes for a wide helix diameter and can sequester metal ions on the inner wall of the helix cavity. Crystallographic studies and NMR titrations show that part of the metal coordination sphere remains available and may then promote the binding of a guest within the cavity. In addition to metal coordination, binding of the guest is assisted by cooperative interactions with the helix host, thereby resulting in significant enhancements depending on the foldamer sequence, and in slow guest capture and release on the NMR time scale. In the absence of metal ions, the pyridazine-pyridine-pyridazine monomer promotes an extended conformation of the foldamer that results in aggregation, including the formation of an intertwined duplex. | |
dc.title.en | Metal-Coordination-Assisted Folding and Guest Binding in Helical Aromatic Oligoamide Molecular Capsules | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/anie.201701693 | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Angewandte Chemie-International Edition | |
bordeaux.page | 6823-6827 | |
bordeaux.volume | 56 | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.issue | 24 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie-International%20Edition&rft.date=2017-06-06&rft.volume=56&rft.issue=24&rft.spage=6823-6827&rft.epage=6823-6827&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=HOREAU,%20Maxime&LAUTRETTE,%20Guillaume&WICHER,%20Barbara&BLOT,%20Virginie&LEBRETON,%20Jacques&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |