Tuning Thermoresponsive Properties of Cationic Elastin-like Polypeptides by Varying Counterions and Side-Chains
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | PETITDEMANGE, Rosine | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | BATAILLE, Laure | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | BATHANY, Katell | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | GARBAY, Bertrand
ORCID: 0000-0001-5756-2627 IDREF: 033777551 | |
dc.contributor.author | DEMING, Timothy J. | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020-07-09T14:16:41Z | |
dc.date.available | 2020-07-09T14:16:41Z | |
dc.date.issued | 2017-04 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10282 | |
dc.description.abstractEn | We report the synthesis of methionine-containing recombinant elastin-like polypeptides (ELPs) of different lengths that contain periodically spaced methionine residues. These ELPs were chemoselectively alkylated at all methionine residues to give polycationic derivatives. Some of these samples were found to possess solubility transitions in water, where the temperature of these transitions varied with ELP concentration, nature of the methionine alkylating group, and nature of the sulfonium counterions. These studies show that introduction and controlled spacing of methionine sulfonium residues into ELPs can be used as a means both to tune their solubility transition temperatures in water using a variety of different parameters and to introduce new side-chain functionality. | |
dc.title.en | Tuning Thermoresponsive Properties of Cationic Elastin-like Polypeptides by Varying Counterions and Side-Chains | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1021/acs.bioconjchem.7b00082 | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Bioconjugate chemistry | |
bordeaux.page | 1403-1412 | |
bordeaux.volume | 28 | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.issue | 5 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioconjugate%20chemistry&rft.date=2017-04&rft.volume=28&rft.issue=5&rft.spage=1403-1412&rft.epage=1403-1412&rft.au=PETITDEMANGE,%20Rosine&GARANGER,%20Elisabeth&BATAILLE,%20Laure&BATHANY,%20Katell&GARBAY,%20Bertrand&rft.genre=article |
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