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Impact of Rapeseed and Soy Lecithin on Postprandial Lipid Metabolism, Bile Acid Profile, and Gut Bacteria in Mice

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorROBERT, C.
dc.contributor.authorBUISSON, C.
dc.contributor.authorLAUGERETTE, F.
dc.contributor.authorABROUS, H.
dc.contributor.authorRAINTEAU, D.
dc.contributor.authorHUMBERT, L.
dc.contributor.authorVANDE WEGHE, J.
dc.contributor.authorMEUGNIER, E.
dc.contributor.authorLOIZON, E.
dc.contributor.authorCAILLET, F.
dc.contributor.authorVAN DORSSELAER, B.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorURDACI, Maria C.
dc.contributor.authorVAYSSE, C.
dc.contributor.authorMICHALSKI, M. C.
dc.date.accessioned2021-07-07T14:10:35Z
dc.date.available2021-07-07T14:10:35Z
dc.date.issued2021
dc.identifier.issn1613-4125en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/95016
dc.description.abstractEnScope Synthetic emulsifiers have recently been shown to promote metabolic syndrome and considerably alter gut microbiota. Yet, data are lacking regarding the effects of natural emulsifiers, such as plant lecithins rich in essential alpha-linolenic acid (ALA), on gut and metabolic health. Methods and Results For 5 days, male Swiss mice are fed diets containing similar amounts of ALA and 0, 1, 3, or 10% rapeseed lecithin (RL) or 10% soy lecithin (SL). Following an overnight fast, they are force-fed the same oil mixture and euthanized after 90 minutes. The consumption of lecithin significantly increased fecal levels of the Clostridium leptum group (p = 0.0004), regardless of origin or dose, without altering hepatic or intestinal expression of genes of lipid metabolism. 10%-RL increased ALA abundance in plasma triacylglycerols at 90 minutes, reduced cecal bile acid hydrophobicity, and increased their sulfatation, as demonstrated by the increased hepatic RNA expression of Sult2a1 (p = 0.037) and cecal cholic acid-7 sulfate (CA-7S) concentration (p = 0.05) versus 0%-lecithin. Conclusion After only 5 days, nutritional doses of RL and SL modified gut bacteria in mice, by specifically increasing C. leptum group. RL also increased postprandial ALA abundance and induced beneficial modifications of the bile acid profile. ALA-rich lecithins, especially RL, may then appear as promising natural emulsifiers.
dc.language.isoENen_US
dc.subject.enabsorption
dc.subject.enfood additive
dc.subject.enintestine
dc.subject.ennutrition
dc.subject.enphospholipid
dc.title.enImpact of Rapeseed and Soy Lecithin on Postprandial Lipid Metabolism, Bile Acid Profile, and Gut Bacteria in Mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/mnfr.202001068en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalMolecular nutrition & food researchen_US
bordeaux.volume65en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03251974
hal.exportfalse
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