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dc.rights.licenseopenen_US
dc.contributor.authorKNOPMAN, David S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorPETERSEN, Ronald C.
dc.contributor.authorCHETELAT, Gael
dc.contributor.authorHOLTZMAN, David M.
dc.contributor.authorHYMAN, Bradley T.
dc.contributor.authorNIXON, Ralph A.
dc.contributor.authorJONES, David T.
dc.date.accessioned2021-07-07T08:01:24Z
dc.date.available2021-07-07T08:01:24Z
dc.date.issued2021-05-13
dc.identifier.issn2056-676xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/95009
dc.description.abstractEnAlzheimer disease (AD) is biologically defined by the presence of beta-amyloid-containing plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic neurodegenerative disease that causes an amnestic cognitive impairment in its prototypical presentation and non-amnestic cognitive impairment in its less common variants. AD is a common cause of cognitive impairment acquired in midlife and late-life but its clinical impact is modified by other neurodegenerative and cerebrovascular conditions. This Primer conceives of AD biology as the brain disorder that results from a complex interplay of loss of synaptic homeostasis and dysfunction in the highly interrelated endosomal/lysosomal clearance pathways in which the precursors, aggregated species and post-translationally modified products of Abeta and tau play important roles. Therapeutic endeavours are still struggling to find targets within this framework that substantially change the clinical course in persons with AD.
dc.language.isoENen_US
dc.subject.enAlzheimer's disease
dc.subject.enDiagnostic markers
dc.subject.enTranslational research
dc.title.enAlzheimer disease
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41572-021-00269-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33986301en_US
bordeaux.journalNature reviews Disease primersen_US
bordeaux.page33en_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03280125
hal.version1
hal.date.transferred2021-07-07T08:01:28Z
hal.exporttrue
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