Multidrug-resistant tuberculosis imported into low-incidence countries-a GeoSentinel analysis, 2008-2020
| dc.rights.license | open | en_US |
| dc.contributor.author | EIMER, Johannes | |
| dc.contributor.author | PATIMETEEPORN, Calvin | |
| dc.contributor.author | JENSENIUS, Mogens | |
| dc.contributor.author | GKRANIA-KLOTSAS, Effrossyni | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUVIGNAUD, Alexandre | |
| dc.contributor.author | BARNETT, Elizabeth D. | |
| dc.contributor.author | HOCHBERG, Natasha S. | |
| dc.contributor.author | CHEN, Lin H. | |
| dc.contributor.author | TRIGO-ESTEBAN, Elena | |
| dc.contributor.author | GERTLER, Maximilian | |
| dc.contributor.author | GREENAWAY, Christina | |
| dc.contributor.author | GROBUSCH, Martin P. | |
| dc.contributor.author | ANGELO, Kristina M. | |
| dc.contributor.author | HAMER, Davidson H. | |
| dc.contributor.author | CAUMES, Eric | |
| dc.contributor.author | ASGEIRSSON, Hilmir | |
| dc.date.accessioned | 2021-07-05T10:28:03Z | |
| dc.date.available | 2021-07-05T10:28:03Z | |
| dc.date.issued | 2021-05-12 | |
| dc.identifier.issn | 1195-1982 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/94979 | |
| dc.description.abstractEn | BACKGROUND: Early detection of imported multidrug-resistant tuberculosis (MDR-TB) is crucial, but knowledge gaps remain about migration- and travel-associated MDR-TB epidemiology. The aim was to describe epidemiologic characteristics among international travelers and migrants with MDR-TB. METHODS: Clinician-determined and microbiologically confirmed MDR-TB diagnoses deemed to be related to travel or migration were extracted from GeoSentinel, a global surveillance network of travel and tropical medicine clinics, from January 2008 through December 2020. MDR-TB was defined as resistance to both isoniazid and rifampicin. Additional resistance to either a fluoroquinolone or a second-line injectable drug was categorized as pre-extensively drug-resistant (pre-XDR) TB, and as extensively drug-resistant (XDR) TB when resistance was detected for both. Sub-analyses were performed based on degree of resistance and country of origin. RESULTS: Of 201 patients, 136 had MDR-TB (67.7%), 25 had XDR-TB (12.4%), 23 had pre-XDR TB (11.4%), and 17 had unspecified MDR- or XDR-TB (8.5%); 196 (97.5%) were immigrants, of which 92 (45.8%) originated from the former Soviet Union. The median interval from arrival to presentation was 154 days (interquartile range [IQR]: 10-751 days); 34.3% of patients presented within 1 month after immigration, 30.9% between 1 and 12 months, and 34.9% after ≥1 year. Pre-XDR- and XDR-TB patients from the former Soviet Union other than Georgia presented earlier than those with MDR-TB (26 days [IQR: 8-522] vs. 369 days [IQR: 84-827]) while patients from Georgia presented very early, irrespectively of the level of resistance (8 days [IQR: 2-18] vs. 2 days [IQR: 1-17]). CONCLUSIONS: MDR-TB is uncommon in traditional travellers. Purposeful medical migration may partly explain differences in time to presentation among different groups. Public health resources are needed to better understand factors contributing to cross-border MDR-TB spread and to develop strategies to optimize care of TB-infected patients in their home countries before migration. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Travel | |
| dc.subject.en | epidemiology | |
| dc.subject.en | Immigration | |
| dc.subject.en | Migrant | |
| dc.subject.en | Medical migration | |
| dc.subject.en | Extensively drug-resistant tuberculosis | |
| dc.subject.en | MDR-TB | |
| dc.title.en | Multidrug-resistant tuberculosis imported into low-incidence countries-a GeoSentinel analysis, 2008-2020 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/jtm/taab069 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33987682 | en_US |
| bordeaux.journal | Journal of Travel Medicine | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03278070 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-07-05T10:28:07Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Travel%20Medicine&rft.date=2021-05-12&rft.eissn=1195-1982&rft.issn=1195-1982&rft.au=EIMER,%20Johannes&PATIMETEEPORN,%20Calvin&JENSENIUS,%20Mogens&GKRANIA-KLOTSAS,%20Effrossyni&DUVIGNAUD,%20Alexandre&rft.genre=article |
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