Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ANDRE, Perrine | |
| dc.contributor.author | PAIS DE BARROS, Jean-Paul | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MERLE, Benedicte
ORCID: 0000-0003-1332-0954 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cécile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| dc.date.accessioned | 2021-07-05T08:01:51Z | |
| dc.date.available | 2021-07-05T08:01:51Z | |
| dc.date.issued | 2021-05-24 | |
| dc.identifier.issn | 0002-9165 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/94962 | |
| dc.description.abstractEn | BACKGROUND: LPS-type endotoxins, naturally found in the gut microbiota, are recognized as triggers of inflammation and emerge as detrimental factors of healthy aging. Nutrition represents a promising strategy to reduce LPS burden, yet little is known about the relation of diet to circulating LPS concentrations. OBJECTIVE: The aim was to evaluate the associations between food groups, dietary patterns, and circulating 3-hydroxy fatty acids (3-OH FAs), a proxy of LPS burden. METHODS: In a cross-sectional study of 698 French older community-dwelling individuals, 3-OH FA concentrations were measured by LC-tandem MS. Dietary patterns were determined using food-frequency questionnaires. Adherence to a Mediterranean-type diet was computed according to the consumption of 8 food groups (fruits, vegetables, legumes, cereals, fish, olive oil, meat, and dairy products) and alcohol intake (range: 0, low adherence, to 18, high adherence). Three a posteriori dietary patterns were derived from factor analysis: complex carbohydrate (rich in rice, pasta, eggs, poultry, and potatoes), traditional (rich in alcohol, meat, processed meats-cold cuts, and legumes), and prudent (rich in vegetables and fruits and low in cookies) diets. Linear regression models were applied. RESULTS: The frequency of consumption of each food group was not associated with 3-OH FA concentrations. Greater adherence to both the Mediterranean diet and the prudent diet were associated with lower circulating 3-OH FAs (β [95% CI] for each additional point of score: -0.12 [-0.22, -0.01] and -0.27 [-0.48, -0.07], respectively). In contrast, greater adherence to the traditional diet was associated with higher concentration of 3-OH FAs (β [95% CI] 0.22 [0.001, 0.46]). The adherence to the complex-carbohydrate diet was not associated with 3-OH FA concentrations. CONCLUSIONS: Based on 2 complementary approaches, the identified plant-based dietary patterns were associated with lower 3-OH FA concentrations, and thus a lower LPS burden, which is considered a potent trigger of inflammatory response. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Dietary pattern | |
| dc.subject.en | Mediterranean diet | |
| dc.subject.en | Principal components analysis | |
| dc.subject.en | Lipopolysaccharides (LPS) | |
| dc.subject.en | Endotoxins | |
| dc.subject.en | Elderly | |
| dc.subject.en | 3C study | |
| dc.subject.en | Alienor study | |
| dc.title.en | Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ajcn/nqab126 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34036325 | en_US |
| bordeaux.journal | American Journal of Clinical Nutrition | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03277825 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-07-05T08:01:55Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Clinical%20Nutrition&rft.date=2021-05-24&rft.eissn=0002-9165&rft.issn=0002-9165&rft.au=ANDRE,%20Perrine&PAIS%20DE%20BARROS,%20Jean-Paul&MERLE,%20Benedicte&SAMIERI,%20Cecilia&HELMER,%20Catherine&rft.genre=article |
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