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A model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus

dc.rights.licenseopen
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALELLI, Irene
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierColumbia University Medical Center [CUMC]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPASIN, Chloe
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Mélanie
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorCRAUSTE, Fabien
hal.structure.identifierJanssen Pharmaceutica [Beerse]
dc.contributor.authorVAN EFFELTERRE, Thierry
hal.structure.identifierJanssen Vaccines & Prevention [Leiden]
dc.contributor.authorBOCKSTAL, Viki
hal.structure.identifierJanssen Vaccines & Prevention [Leiden]
dc.contributor.authorSOLFOROSI, Laura
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIÉBAUT, Rodolphe
dc.date.accessioned2020-07-06T14:57:43Z
dc.date.available2020-07-06T14:57:43Z
dc.date.issued2020
dc.identifier.issn0022-5193
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8668
dc.description.abstractEnThe 2014-2016 Ebola outbreak in West Africa has triggered accelerated development of several preventive vaccines against Ebola virus. Under the EBOVAC1 consortium, three phase I studies were carried out to assess safety and immunogenicity of a two-dose heterologous vaccination regimen developed by Janssen Vaccines and Prevention in collaboration with Bavarian Nordic. To describe the immune responses induced by the two-dose heterologous vaccine regimen, we propose a mechanistic ODE based model, which takes into account the role of immunological memory. We perform identifiability and sensitivity analysis of the proposed model to establish which kind of biological data are ideally needed in order to accurately estimate parameters, and additionally, which of those are non-identifiable based on the available data. Antibody concentrations data from phase I studies have been used to calibrate the model and show its ability in reproducing the observed antibody dynamics. Together with other factors, the establishment of an effective and reactive immunological memory is of pivotal importance for several prophylactic vaccines. We show that introducing a memory compartment in our calibrated model allows to evaluate the magnitude of the immune response induced by a booster dose and its long-term persistence afterwards.
dc.language.isoen
dc.publisherElsevier
dc.subject.enCalibration
dc.subject.enHeterologous vaccination
dc.subject.enSensitivity analysis
dc.subject.enIdentifiability analysis
dc.subject.enMechanistic modeling
dc.subject.enImmunological memory
dc.subject.enVaccination
dc.subject.enEbola Virus
dc.title.enA model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jtbi.2020.110254
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Vaccinologie
dc.subject.halMathématiques [math]
bordeaux.journalJournal of Theoretical Biology
bordeaux.page110254
bordeaux.volume495
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINSERM
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedoui
hal.identifierhal-02879917
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02879917v1
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