Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PILLERON, S. | |
| dc.contributor.author | WEBER, D. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PERES, Karine | |
| dc.contributor.author | COLPO, M. | |
| dc.contributor.author | GOMEZ-CABRERO, D. | |
| dc.contributor.author | STUETZ, W. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529 IDREF: 058586105 | |
| dc.contributor.author | FERRUCCI, L. | |
| dc.contributor.author | BANDINELLI, S. | |
| dc.contributor.author | GARCIA-GARCIA, F. J. | |
| dc.contributor.author | GRUNE, T. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| dc.date.accessioned | 2020-07-03T14:07:31Z | |
| dc.date.available | 2020-07-03T14:07:31Z | |
| dc.date.issued | 2019-02 | |
| dc.identifier.issn | 1436-6215 (Electronic) 1436-6207 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8576 | |
| dc.description.abstractEn | PURPOSE: To investigate the cross-sectional and prospective associations between patterns of serum fat-soluble micronutrients and frailty in four European cohorts of older adults 65 years of age and older. METHODS: Participants from the Three-City (Bordeaux, France), AMI (Gironde, France), TSHA (Toledo, Spain) and InCHIANTI (Tuscany, Italy) cohorts with available data on serum alpha-carotene, beta-carotene, lycopene, cryptoxanthin, lutein + zeaxanthin, retinol, alpha-tocopherol, gamma-tocopherol and 25-hydroxyvitamin D3 (25(OH)D) were included. A principal component (PC) analysis was used to derive micronutrient patterns. Frailty was defined using Fried's criteria. Multivariate logistic regression models adjusted for socio-demographic and health-related covariates were performed to assess the association between micronutrient patterns and prevalent frailty in 1324 participants, and the risk of frailty in 915 initially non-frail participants. RESULTS: Three different patterns were identified: the first pattern was characterized by higher serum carotenoids and alpha-tocopherol levels; the second was characterized by high loadings for serum vitamins A and E levels and low loadings for carotenes level; the third one had the highest loading for serum 25(OH)D and cryptoxanthin level and the lowest loading for vitamin A and E. A significant cross-sectional association was only observed between the seconnd PC and prevalent frailty (p = 0.02). Compared to the highest quartile, participants in the lowest quartile-i.e., high carotenes and low vitamins E and A levels-had higher odds of frailty (Odds ratio = 2.2; 95% confidence interval 1.3-3.8). No association with the risk of frailty was observed. CONCLUSIONS: These findings suggest that some specific micronutrient patterns are markers but not predictors of frailty in these European cohorts of older adults. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | LEHA | |
| dc.subject.en | SEPIA | |
| dc.title.en | Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults | |
| dc.title.alternative | Eur J Nutr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00394-017-1602-0 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29380043 | en_US |
| bordeaux.journal | European Journal of Nutrition | en_US |
| bordeaux.page | 379-389 | en_US |
| bordeaux.volume | 58 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03162489 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-08T14:11:53Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Nutrition&rft.date=2019-02&rft.volume=58&rft.issue=1&rft.spage=379-389&rft.epage=379-389&rft.eissn=1436-6215%20(Electronic)%201436-6207%20(Linking)&rft.issn=1436-6215%20(Electronic)%201436-6207%20(Linking)&rft.au=PILLERON,%20S.&WEBER,%20D.&PERES,%20Karine&COLPO,%20M.&GOMEZ-CABRERO,%20D.&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||