Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases
| dc.rights.license | open | en_US |
| dc.contributor.author | MENGUY, S. | |
| dc.contributor.author | BEYLOT-BARRY, M. | |
| dc.contributor.author | PARRENS, M. | |
| dc.contributor.author | LEDARD, A. P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FRISON, Eric | |
| dc.contributor.author | COMOZ, F. | |
| dc.contributor.author | BATTISTELLA, M. | |
| dc.contributor.author | SZABLEWSKI, V. | |
| dc.contributor.author | BALME, B. | |
| dc.contributor.author | CROUE, A. | |
| dc.contributor.author | FRANCK, F. | |
| dc.contributor.author | ORTONNE, N. | |
| dc.contributor.author | TOURNIER, E. | |
| dc.contributor.author | LAMANT, L. | |
| dc.contributor.author | CARLOTTI, A. | |
| dc.contributor.author | DE MURET, A. | |
| dc.contributor.author | LE GALL, F. | |
| dc.contributor.author | LORTON, M. H. | |
| dc.contributor.author | MERLIO, J. P. | |
| dc.contributor.author | VERGIER, B. | |
| dc.date.accessioned | 2020-07-01T07:36:08Z | |
| dc.date.available | 2020-07-01T07:36:08Z | |
| dc.date.issued | 2019-06 | |
| dc.identifier.issn | 1365-2559 (Electronic) 0309-0167 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8353 | |
| dc.description.abstractEn | AIMS: We applied the 2017 WHO classification criteria to categorize a series of 64 primary cutaneous large B-cell lymphomas (PCLBCLs), containing a majority (80%) of large-cells and a proliferative rate 40%, raising the problem of the differential diagnosis between PCLBCLs, leg type (PCLBCLs-LT) or primary cutaneous follicle center lymphomas with large cell morphology (PCFCLs-LC). The aims were to determine reproducibility and prognostic relevance of the 2017 WHO criteria. METHODS AND RESULTS: Morphology and phenotype identified 32 PCLBCLs-LT and 25 PCFCLs-LC; 7 cases (11%) remained unclassified. Morphology was less reproducible than immunophenotype. Pertinent markers for the differential diagnosis were MUM1, FOXP1, CD10 and IgM. BCL2 and BCL6 were expressed by both PCFCLs-LC and PCLBCLs-LT in substantial percentages. Neither Ki67 nor P63 expression had diagnostic value. MYD88 was only found mutated in PCLBCLs-LT (n = 22, 69%). Using Hans/Hans modified algorithms, 23 out of 25 PCFCLs-LC had germinal center (GC) status and the 32 PCLBCLs-LT, non-GC status. Overall survival was poorer for PCLBCLs-LT than PCFCLs-LC (P=0.0002). Non-GC cases had poorer overall survival than GC cases (P=0.0007). In PCLBCLs-LT, MYC expression was associated with cutaneous relapses (P=0.014). Applying GC/non-GC status for unclassified cases, only a single case remained discordant. CONCLUSIONS: Our results support the 2017 WHO classification criteria for PCLBCL diagnosis. The Hans modified algorithm using CD10 and MUM1 distinguished PCFCLs-LC from PCLBCLs-LT with optimal diagnostic value without requiring BCL6 immunolabeling (poor reproducible). Rare unclassified cases may be a provisionally heterogeneous subgroup for which GC/non-GC status (relevant for prognosis) may guide therapeutic decisions. This article is protected by copyright. All rights reserved. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | USMR | |
| dc.title.en | Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases | |
| dc.title.alternative | Histopathology | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/his.13832 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30715765 | en_US |
| bordeaux.journal | Histopathology | en_US |
| bordeaux.page | 1067-1080 | en_US |
| bordeaux.volume | 74 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Histopathology&rft.date=2019-06&rft.volume=74&rft.issue=7&rft.spage=1067-1080&rft.epage=1067-1080&rft.eissn=1365-2559%20(Electronic)%200309-0167%20(Linking)&rft.issn=1365-2559%20(Electronic)%200309-0167%20(Linking)&rft.au=MENGUY,%20S.&BEYLOT-BARRY,%20M.&PARRENS,%20M.&LEDARD,%20A.%20P.&FRISON,%20Eric&rft.genre=article |
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