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Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

dc.rights.licenseopenen_US
dc.contributor.authorMATTEI, J. C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBROUSTE, V.
dc.contributor.authorTERRIER, P.
dc.contributor.authorBONVALOT, S.
dc.contributor.authorLECESNE, A.
dc.contributor.authorSTOECKLE, E.
dc.contributor.authorITALIANO, A.
dc.contributor.authorRANCHERE-VINCE, D.
dc.contributor.authorMEEUS, P.
dc.contributor.authorLAE, M.
dc.contributor.authorROSSET, P.
dc.contributor.authorROCHWERGER, A.
dc.contributor.authorCOINDRE, J. M.
dc.contributor.authorSALAS, S.
dc.date.accessioned2020-06-30T07:44:54Z
dc.date.available2020-06-30T07:44:54Z
dc.date.issued2019-03
dc.identifier.issn1096-9098 (Electronic) 0022-4790 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8318
dc.description.abstractEnBACKGROUND AND OBJECTIVES: Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS). METHODS: From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Demographics, tumor type, treatment modalities, and latest follow-up status were collected. Primary endpoints were overall survival and local/metastatic recurrence incidences. RESULTS: Two hundred five DESTS and 3001 OLSTS were included. The patients were younger, with more female and smaller tumors in DESTS. There were more clear cell/epithelioid sarcomas, synovial sarcomas, and myxoid liposarcomas vs more dedifferentiated liposarcomas in OLSTS. DESTS tumors were less irradiated and more often amputated (24.3% vs 3.4%). The five-year survival rate was 78.2% compared to 68.6% in OLSTS and after multivariate analysis, STS localization did not impact survival or local/metastatic recurrence. CONCLUSION: Though rare and smaller than other limb localizations, DESTS are to be considered as aggressive. Despite a higher amputation rate, the prognosis remains the same as in OLSTS. Limb sparing vs amputation should be carefully assessed in DESTS, especially if grade 3 or of a poor prognosis histological subtype.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enDistal extremities soft tissue sarcomas: Are they so different from other limb localizations?
dc.title.alternativeJ Surg Oncolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jso.25359en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30609044en_US
bordeaux.journalJournal of surgical oncologyen_US
bordeaux.page479-488en_US
bordeaux.volume119en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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