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B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape

dc.rights.licenseopenen_US
dc.contributor.authorLUCAR, O.
dc.contributor.authorSADJO DIALLO, M.
dc.contributor.authorBAYARD, C.
dc.contributor.authorSAMRI, A.
dc.contributor.authorTARANTINO, N.
dc.contributor.authorDEBRE, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorBRUN-VEZINET, F.
dc.contributor.authorMATHERON, S.
dc.contributor.authorCHEYNIER, R.
dc.contributor.authorVIEILLARD, V.
dc.contributor.authorGROUP, Anrs Co Immunovir- Study
dc.date.accessioned2020-06-26T08:14:45Z
dc.date.available2020-06-26T08:14:45Z
dc.date.issued2019-01-27
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8210
dc.description.abstractEnOBJECTIVE: HIV-1 and HIV-2 differ notably in their epidemiology, with worldwide HIV-1 spread and HIV-2 mainly confined to West Africa. Natural killer (NK) cells are critical antiviral effectors of the immune system; however, limited information is available about these innate effector cells during HIV-2 infection. METHOD: In this study, 24 untreated HIV-2-infected patients were analyzed and compared with 21 long-term nonprogressor and 10 controller HIV-1 patients, and healthy donors. Extensive phenotype and functional NK-cell characteristics, as well as ligands of activating NK receptors involved in NK lysis were determined by flow cytometry. RESULTS: We report in HIV-2 patients a very significant reduced expression of the activating NKp30 receptor (P < 0.0001) on NK cells, much higher than observed in HIV-1 patients. The impaired expression of NKp30 is correlated negatively with HLA-DR (r = -0.5970; P = 0.0002), and positively with both NKG2A (r = 0.5324; P < 0.0001) and Siglec-7 (r = 0.5621; P = 0.0004). HIV-2 patients with NKp30 NK cells displayed overproduction of IFN-gamma (P < 0.0001) associated with impaired cytolytic function when tested against target cells expressing surface B7-H6. This cellular ligand of NKp30 is strongly detectable as a surface molecule on CD4 T cells infected by HIV-2. CONCLUSION: Altogether, our data suggested that the defective expression of NKp30 may be induced by the chronic engagement of this receptor by B7-H6 expressed on HIV-2-infected target cells. This represents a novel mechanism by which the chronic ligand exposure by the viral environment may subvert NK-cell-mediated function to establish persistent HIV-2 infection.
dc.language.isoENen_US
dc.subject.enSISTM
dc.title.enB7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000002061en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30325780en_US
bordeaux.journalAIDS (London, England)en_US
bordeaux.page23-32en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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