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A large-scale exome array analysis of venous thromboembolism

dc.rights.licenseopenen_US
dc.contributor.authorLINDSTROM, S.
dc.contributor.authorBRODY, J. A.
dc.contributor.authorTURMAN, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGERMAIN, Marine
dc.contributor.authorBARTZ, T. M.
dc.contributor.authorSMITH, E. N.
dc.contributor.authorCHEN, M. H.
dc.contributor.authorPUURUNEN, M.
dc.contributor.authorCHASMAN, D.
dc.contributor.authorHASSLER, J.
dc.contributor.authorPANKRATZ, N.
dc.contributor.authorBASU, S.
dc.contributor.authorGUAN, W.
dc.contributor.authorGYORGY, B.
dc.contributor.authorIBRAHIM, M.
dc.contributor.authorEMPANA, J. P.
dc.contributor.authorOLASO, R.
dc.contributor.authorJACKSON, R.
dc.contributor.authorBRAEKKAN, S. K.
dc.contributor.authorMCKNIGHT, B.
dc.contributor.authorDELEUZE, J. F.
dc.contributor.authorO'DONNELL, C. J.
dc.contributor.authorJOUVEN, X.
dc.contributor.authorFRAZER, K. A.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorWIGGINS, K. L.
dc.contributor.authorTAYLOR, K.
dc.contributor.authorREINER, A. P.
dc.contributor.authorHECKBERT, S. R.
dc.contributor.authorKOOPERBERG, C.
dc.contributor.authorRIDKER, P.
dc.contributor.authorHANSEN, J. B.
dc.contributor.authorTANG, W.
dc.contributor.authorJOHNSON, A. D.
dc.contributor.authorMORANGE, P. E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorKRAFT, P.
dc.contributor.authorSMITH, N. L.
dc.contributor.authorKABRHEL, C.
dc.contributor.authorCONSORTIUM, Invent
dc.date.accessioned2020-06-26T07:16:19Z
dc.date.available2020-06-26T07:16:19Z
dc.date.issued2019-06
dc.identifier.issn1098-2272 (Electronic) 0741-0395 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8204
dc.description.abstractEnAlthough recent Genome-Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome-wide search for low-frequency variants that affect the risk of venous thromboembolism (VTE). We conducted a meta-analysis of 11 studies comprising 8,332 cases and 16,087 controls of European ancestry and 382 cases and 1,476 controls of African American ancestry genotyped with the Illumina HumanExome BeadChip. We used the seqMeta package in R to conduct single variant and gene-based rare variant tests. In the single variant analysis, we limited our analysis to the 64,794 variants with at least 40 minor alleles across studies (minor allele frequency [MAF] ~0.08%). We confirmed associations with previously identified VTE loci, including ABO, F5, F11, and FGA. After adjusting for multiple testing, we observed no novel significant findings in single variant or gene-based analysis. Given our sample size, we had greater than 80% power to detect minimum odds ratios greater than 1.5 and 1.8 for a single variant with MAF of 0.01 and 0.005, respectively. Larger studies and sequence data may be needed to identify novel low-frequency and rare variants associated with VTE risk.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enA large-scale exome array analysis of venous thromboembolism
dc.title.alternativeGenet Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/gepi.22187en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30659681en_US
bordeaux.journalGenetic epidemiologyen_US
bordeaux.page449-457en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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