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Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

dc.rights.licenseopenen_US
dc.contributor.authorKLARIN, D.
dc.contributor.authorBUSENKELL, E.
dc.contributor.authorJUDY, R.
dc.contributor.authorLYNCH, J.
dc.contributor.authorLEVIN, M.
dc.contributor.authorHAESSLER, J.
dc.contributor.authorARAGAM, K.
dc.contributor.authorCHAFFIN, M.
dc.contributor.authorHAAS, M.
dc.contributor.authorLINDSTROM, S.
dc.contributor.authorASSIMES, T. L.
dc.contributor.authorHUANG, J.
dc.contributor.authorMIN LEE, K.
dc.contributor.authorSHAO, Q.
dc.contributor.authorHUFFMAN, J. E.
dc.contributor.authorKABRHEL, C.
dc.contributor.authorHUANG, Y.
dc.contributor.authorSUN, Y. V.
dc.contributor.authorVUJKOVIC, M.
dc.contributor.authorSALEHEEN, D.
dc.contributor.authorMILLER, D. R.
dc.contributor.authorREAVEN, P.
dc.contributor.authorDUVALL, S.
dc.contributor.authorBODEN, W. E.
dc.contributor.authorPYARAJAN, S.
dc.contributor.authorREINER, A. P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorHENKE, P.
dc.contributor.authorKOOPERBERG, C.
dc.contributor.authorGAZIANO, J. M.
dc.contributor.authorCONCATO, J.
dc.contributor.authorRADER, D. J.
dc.contributor.authorCHO, K.
dc.contributor.authorCHANG, K. M.
dc.contributor.authorWILSON, P. W. F.
dc.contributor.authorSMITH, N. L.
dc.contributor.authorO'DONNELL, C. J.
dc.contributor.authorTSAO, P. S.
dc.contributor.authorKATHIRESAN, S.
dc.contributor.authorOBI, A.
dc.contributor.authorDAMRAUER, S. M.
dc.contributor.authorNATARAJAN, P.
dc.date.accessioned2020-06-25T09:11:46Z
dc.date.available2020-06-25T09:11:46Z
dc.date.issued2019-11-01
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8189
dc.description.abstractEnVenous thromboembolism is a significant cause of mortality(1), yet its genetic determinants are incompletely defined. We performed a discovery genome-wide association study in the Million Veteran Program and UK Biobank, with testing of approximately 13 million DNA sequence variants for association with venous thromboembolism (26,066 cases and 624,053 controls) and meta-analyzed both studies, followed by independent replication with up to 17,672 venous thromboembolism cases and 167,295 controls. We identified 22 previously unknown loci, bringing the total number of venous thromboembolism-associated loci to 33, and subsequently fine-mapped these associations. We developed a genome-wide polygenic risk score for venous thromboembolism that identifies 5% of the population at an equivalent incident venous thromboembolism risk to carriers of the established factor V Leiden p.R506Q and prothrombin G20210A mutations. Our data provide mechanistic insights into the genetic epidemiology of venous thromboembolism and suggest a greater overlap among venous and arterial cardiovascular disease than previously thought.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enGenome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-019-0519-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31676865en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page1574-1579en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209570
hal.version1
hal.date.transferred2021-04-27T10:06:31Z
hal.exporttrue
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