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Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy

dc.rights.licenseopenen_US
dc.contributor.authorGRAS, L.
dc.contributor.authorMAY, M.
dc.contributor.authorRYDER, L. P.
dc.contributor.authorTRICKEY, A.
dc.contributor.authorHELLEBERG, M.
dc.contributor.authorOBEL, N.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorGUEST, J.
dc.contributor.authorGILL, J.
dc.contributor.authorCRANE, H.
dc.contributor.authorDIAS LIMA, V.
dc.contributor.authorD'ARMINIO MONFORTE, A.
dc.contributor.authorSTERLING, T. R.
dc.contributor.authorMIRO, J.
dc.contributor.authorMORENO, S.
dc.contributor.authorSTEPHAN, C.
dc.contributor.authorSMITH, C.
dc.contributor.authorTATE, J.
dc.contributor.authorSHEPHERD, L.
dc.contributor.authorSAAG, M.
dc.contributor.authorRIEGER, A.
dc.contributor.authorGILLOR, D.
dc.contributor.authorCAVASSINI, M.
dc.contributor.authorMONTERO, M.
dc.contributor.authorINGLE, S. M.
dc.contributor.authorREISS, P.
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorWIT, Fwnm
dc.contributor.authorSTERNE, J.
dc.contributor.authorDE WOLF, F.
dc.contributor.authorGESKUS, R.
dc.contributor.authorANTIRETROVIRAL THERAPY COHORT, Collaboration
dc.date.accessioned2020-06-22T15:20:39Z
dc.date.available2020-06-22T15:20:39Z
dc.date.issued2019-03-01
dc.identifier.issn1944-7884 (Electronic) 1525-4135 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8071
dc.description.abstractEnBACKGROUND: An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4:CD8 ratio during virologically suppressive ART to median levels seen in HIV uninfected individuals more likely and whether restoration depends on gender, age and other individual characteristics. METHODS: We determined median and quartile reference values for CD4 and CD8 cell count and their ratio using cross-sectional data from 2,309 HIV-negative individuals. We used longitudinal measurements of 60,997 HIV-positive individuals from the Antiretroviral Therapy Cohort Collaboration in linear mixed effects models. RESULTS: When baseline CD4 cell counts were higher, higher long-term CD4 cell counts and CD4:CD8 ratios were reached. Highest long-term CD4 cell counts were observed in middle-aged individuals. During the first two years median CD8 cell counts converged towards median reference values. However, changes were small thereafter and long-term CD8 cell count levels were higher than median reference values. Median 8-year CD8 cell counts were higher when ART was started with <250 CD4 cells/mm. Median CD4:CD8 trajectories did not reach median reference values, even when ART was started at 500 cells/mm. DISCUSSION: Starting ART with a CD4 cell count of >/=500 cells/mm makes reaching median reference CD4 cell counts more likely. However, median CD4:CD8 ratio trajectories remained below the median levels of HIV-negative individuals, because of persisting high CD8 cell counts. To what extent these subnormal immunological responses have impact on specific clinical endpoints requires further investigation.This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.language.isoENen_US
dc.subject.enSISTM
dc.subject.enMORPH3Eus
dc.subject.enColl_IDLIC
dc.subject.enColl_ART-CC
dc.title.enDeterminants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy
dc.title.alternativeJ Acquir Immune Defic Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000001913en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30531492en_US
bordeaux.journalJournal of Acquired Immune Deficiency Syndromesen_US
bordeaux.page292-300en_US
bordeaux.volume80en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03161868
hal.version1
hal.date.transferred2021-03-08T09:17:54Z
hal.exporttrue
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