Trypanosoma brucei gambiense excreted/secreted factors impair lipopolysaccharide-induced maturation and activation of human monocyte-derived dendritic cells
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DAUCHY, Frederic-Antoine | |
| dc.contributor.author | CONTIN-BORDES, C. | |
| dc.contributor.author | NZOUMBOU-BOKO, R. | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BONHIVERS, M. | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LANDREIN, N. | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ROBINSON, D. R. | |
| dc.contributor.author | RAMBERT, J. | |
| dc.contributor.author | COURTOIS, P. | |
| dc.contributor.author | DAULOUEDE, S. | |
| dc.contributor.author | VINCENDEAU, P. | |
| dc.date.accessioned | 2020-06-17T10:29:13Z | |
| dc.date.available | 2020-06-17T10:29:13Z | |
| dc.date.issued | 2019-08 | |
| dc.identifier.issn | 0141-9838 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7973 | |
| dc.description.abstractEn | Trypanosoma brucei gambiense, an extracellular eukaryotic flagellate parasite, is the main etiological agent of human African trypanosomiasis (HAT) or sleeping sickness. Dendritic cells (DCs) play a pivotal role at the interface between innate and adaptive immune response and are implicated during HAT. In this study, we investigated the effects of T gambiense and its excreted/secreted factors (ESF) on the phenotype of human monocyte-derived DCs (Mo-DCs). Mo-DCs were cultured with trypanosomes, lipopolysaccharide (LPS), ESF derived from T gambiense bloodstream strain Biyamina (MHOM/SD/82), or both ESF and LPS. Importantly, ESF reduced the expression of the maturation markers HLA-DR and CD83, as well as the secretion of IL-12, TNF-alpha and IL-10, in LPS-stimulated Mo-DCs. During mixed-leucocyte reactions, LPS- plus ESF-exposed DCs induced a non-significant decrease in the IFN-gamma/IL-10 ratio of CD4 + T-cell cytokines. Based on the results presented here, we raise the hypothesis that T gambiense has developed an immune escape strategy through the secretion of paracrine mediators in order to limit maturation and activation of human DCs. The identification of the factor(s) in the T gambiense ESF and of the DCs signalling pathway(s) involved may be important in the development of new therapeutic targets. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.title.en | Trypanosoma brucei gambiense excreted/secreted factors impair lipopolysaccharide-induced maturation and activation of human monocyte-derived dendritic cells | |
| dc.title.alternative | Parasite Immunol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/pim.12632 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31099071 | en_US |
| bordeaux.journal | Parasite Immunol | en_US |
| bordeaux.page | e12632 | en_US |
| bordeaux.volume | 41 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Parasite%20Immunol&rft.date=2019-08&rft.volume=41&rft.issue=8&rft.spage=e12632&rft.epage=e12632&rft.eissn=0141-9838&rft.issn=0141-9838&rft.au=DAUCHY,%20Frederic-Antoine&CONTIN-BORDES,%20C.&NZOUMBOU-BOKO,%20R.&BONHIVERS,%20M.&LANDREIN,%20N.&rft.genre=article |
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