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dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOURANT, Maxime
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORAZIO, Sebastien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPRETERRE, Julie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
ORCID: 0000-0002-0360-573X
IDREF: 58708871
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRIGOTHIER, Claire
dc.date.accessioned2021-06-23T14:34:48Z
dc.date.available2021-06-23T14:34:48Z
dc.date.issued2021-02-20
dc.identifier.issn0931-0509en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79278
dc.description.abstractEnBACKGROUND: Renal impairment (RI), a severe complication in multiple myeloma (MM), is considered as a poor prognostic factor. Patient survival has increased with the use of novel drugs and autologous stem-cell transplantation (ASCT). However, specific evolution of the incidence of RI in MM and its impact on prognosis remain unclear. METHODS: Using a population-based registry of 1038 newly diagnosed MM in Gironde, France, we evaluated the incidence trends of RI in MM patients and assessed net survival according to factors of interest using Pohar-Perme indicator and excess mortality rate regression. We also reviewed 114 cases of MM with RI to describe their clinical outcomes. RESULTS: In our population-based study, 24.6% of MM patients presented with RI (12.9% required haemodialysis). Median survival time was 21 months in patients with RI versus not reached at 3 years for other patients (P < 0.01). Age >73 years, RI, comorbidities and non-use of drugs or ASCT were associated with excess mortality risk. The effect of RI on excess mortality rates was maximum in the first 6 months after diagnosis. In the observational study, median follow-up time was 22.5 months; factors associated with renal response were haematologic response [odds ratio (OR) 6.81; P < 0.01] and previous chronic kidney disease (OR 0.26; P = 0.04). Factors associated with 1-year overall survival were haematological [hazard ratio (HR) 0.13; P < 0.01] and renal response (HR 0.27; P = 0.03). CONCLUSIONS: RI represents an independent negative prognostic factor in MM in the first 6 months after diagnosis. Renal recovery and haematologic response are the strongest markers associated with patient survival.
dc.language.isoENen_US
dc.subject.enIncidence
dc.subject.enKidney injury
dc.subject.enMultiple myeloma
dc.subject.enPrognosis
dc.subject.enSurvival
dc.title.enIncidence, prognostic impact and clinical outcomes of renal impairment in patients with multiple myeloma: a population-based registry
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfz211en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31773154en_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.page482-490en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03269065
hal.version1
hal.date.transferred2021-06-23T14:34:52Z
hal.exporttrue
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