Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case-control study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BALDI, Isabelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DE GRAAF, Lucie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BOUVIER, Ghislaine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GRUBER, Anne | |
| hal.structure.identifier | Imagerie moléculaire et thérapies innovantes en oncologie [IMOTION] | |
| dc.contributor.author | LOISEAU, Hugues | |
| dc.contributor.author | MERYET-FIGUIERE, Matthieu | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ROUSSEAU, Sarah | |
| dc.contributor.author | FABBRO-PERAY, Pascale | |
| dc.contributor.author | LEBAILLY, Pierre | |
| dc.date.accessioned | 2021-06-23T09:47:01Z | |
| dc.date.available | 2021-06-23T09:47:01Z | |
| dc.date.issued | 2021-04-19 | |
| dc.identifier.issn | 1573-7225 (Electronic) 0957-5243 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/79269 | |
| dc.description.abstractEn | BACKGROUND: The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no definitive conclusion. OBJECTIVE: To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study. METHODS: CERENAT is a multicenter case-control study conducted in France in 2004-2006. Data about occupational pesticide uses-in and outside agriculture-were collected during detailed face-to-face interviews and reviewed by experts for consistency and exposure assignment. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated with conditional logistic regression. RESULTS: A total of 596 cases (273 gliomas, 218 meningiomas, 105 others) and 1 192 age- and sex-matched controls selected in the general population were analyzed. Direct and indirect exposures to pesticides in agriculture were respectively assigned to 125 (7.0%) and 629 (35.2%) individuals and exposure outside agriculture to 146 (8.2%) individuals. For overall agricultural exposure, we observed no increase in risk for all brain tumors (OR 1.04, 0.69-1.57) and a slight increase for gliomas (OR 1.37, 0.79-2.39). Risks for gliomas were higher when considering agricultural exposure for more than 10 years (OR 2.22, 0.94-5.24) and significantly trebled in open field agriculture (OR 3.58, 1.20-10.70). Increases in risk were also observed in non-agricultural exposures, especially in green space workers who were directly exposed (OR 1.89, 0.82-4.39), and these were statistically significant for those exposed for over 10 years (OR 2.84, 1.15-6.99). DISCUSSION: These data support some previous findings regarding the potential role of occupational exposures to pesticides in CNS tumors, both inside and outside agriculture. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Central nervous system tumor | |
| dc.subject.en | Glioma | |
| dc.subject.en | Meningioma | |
| dc.subject.en | Etiology | |
| dc.subject.en | Pesticides | |
| dc.subject.en | Agriculture | |
| dc.subject.en | Green spaces | |
| dc.subject.en | Occupational exposures | |
| dc.title.en | Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case-control study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s10552-021-01429-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33876308 | en_US |
| bordeaux.journal | Cancer Causes and Control | en_US |
| bordeaux.page | 773–782 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Agence Française de Sécurité Sanitaire de l'Environnement et du Travail | en_US |
| bordeaux.identifier.funderID | Association pour la Recherche sur le Cancer | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| hal.identifier | hal-03268518 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-06-23T09:47:08Z | |
| hal.export | true | |
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