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A THERMOSENSITIVE LOW MOLECULAR WEIGHT HYDROGEL AS SCAFFOLD FOR TISSUE ENGINEERING

hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorZIANE, Sophia
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorSCHLAUBITZ, Silke
hal.structure.identifierINSERM U1026 [INSERM, U1026]
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierARN : régulations naturelle et artificielle
dc.contributor.authorPATWA, Amit
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorLALANDE, Charlotte
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorBILEM, Ibrahim
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorLEPREUX, Sébastien
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorROUSSEAU, Benoit
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-François
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierARN : régulations naturelle et artificielle
dc.contributor.authorLATXAGUE, Laurent
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierARN : régulations naturelle et artificielle
dc.contributor.authorBARTHÉLÉMY, Philippe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierINSERM U1026 [INSERM, U1026]
dc.contributor.authorCHASSANDE, Olivier
dc.date.accessioned2021-06-10T07:06:01Z
dc.date.available2021-06-10T07:06:01Z
dc.date.issued2012-04-16
dc.identifier.issn1473-2262
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79058
dc.description.abstractEnHydrogels that are non-toxic, easy to use, cytocompatible, injectable and degradable are valuable biomaterials for tissue engineering and tissue repair. However, few compounds currently fulfil these requirements. In this study, we describe the biological properties of a new type of thermosensitive hydrogel based on low-molecular weight glycosyl-nucleosyl-fluorinated (GNF) compound. This gel forms within 25 min by self-assembly of monomers as temperature decreases. It degrades slowly in vitro and in vivo. It induces moderate chronic inflammation and is progressively invaded by host cells and vessels, suggesting good integration to the host environment. Although human adult mesenchymal stem cells derived from adipose tissue (ASC) cannot adhere on the gel surface or within a 3D gel scaffold, cell aggregates grow and differentiate normally when entrapped in the GNF-based gel. Moreover, this hydrogel stimulates osteoblast differentiation of ASC in the absence of osteogenic factors. When implanted in mice, gel-entrapped cell aggregates survive for several weeks in contrast with gel-free spheroids. They are maintained in their original site of implantation where they interact with the host tissue and adhere on the extracellular matrix. They can differentiate in situ into alkaline phosphatase positive osteoblasts, which deposit a calcium phosphate-rich matrix. When injected into subcutaneous sites, gel-encapsulated cells show similar biological properties as implanted gel-cells complexes. These data point GNF-based gels as a novel class of hydrogels with original properties, in particular osteogenic potential, susceptible of providing new therapeutic solutions especially for bone tissue engineering applications.
dc.language.isoen
dc.publisherAO Research Institute Davos
dc.subject.enbiocompatibility
dc.subject.enadipose tissue derived stem cells
dc.subject.enLow molecular weight gel
dc.subject.ensupramolecular assemblies
dc.subject.ennucleoside amphiphiles
dc.title.enA THERMOSENSITIVE LOW MOLECULAR WEIGHT HYDROGEL AS SCAFFOLD FOR TISSUE ENGINEERING
dc.typeArticle de revue
dc.subject.halChimie/Polymères
bordeaux.journaleCells and Materials Journal
bordeaux.page147-160
bordeaux.volume23
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-00817266
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00817266v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eCells%20and%20Materials%20Journal&rft.date=2012-04-16&rft.volume=23&rft.spage=147-160&rft.epage=147-160&rft.eissn=1473-2262&rft.issn=1473-2262&rft.au=ZIANE,%20Sophia&SCHLAUBITZ,%20Silke&MIRAUX,%20Sylvain&PATWA,%20Amit&LALANDE,%20Charlotte&rft.genre=article


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