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An open-label randomized controlled trial of low-dose corticosteroid plus enteric-coated mycophenolate sodium versus standard corticosteroid treatment for minimal change nephrotic syndrome in adults (MSN Study)

hal.structure.identifierService de néphrologie [CHU Henri Mondor]
hal.structure.identifierINSERM U955, équipe 21
dc.contributor.authorREMY, Philippe
hal.structure.identifierService de néphrologie [CHU Henri Mondor]
hal.structure.identifierINSERM U955, équipe 21
dc.contributor.authorAUDARD, Vincent
hal.structure.identifierAssistance Publique-Hôpitaux de Paris, Department of Pathology, Centre hospitalier universitaire Henri Mondor, F-94000 Créteil, France
hal.structure.identifierClinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique [CEpiA]
dc.contributor.authorNATELLA, Pierre André
hal.structure.identifierDepartment of Nephrology and Transplantation, Foch Hospital,
dc.contributor.authorPELLE, Gaëlle
hal.structure.identifierChirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM]
dc.contributor.authorDUSSOL, Bertrand
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorLERAY-MORAGUES, Hélène
hal.structure.identifierService de néphrologie [Rennes]
dc.contributor.authorVIGNEAU, Cécile
hal.structure.identifierService de néphrologie et transplantation
dc.contributor.authorBOUACHI, Khedidja
hal.structure.identifierInstitut Transplantation Urologie et Néphrologie
dc.contributor.authorDANTAL, Jacques
dc.contributor.authorVRIGNEAUD, Laurence
hal.structure.identifierHôpital Européen Georges Pompidou [APHP] [HEGP]
hal.structure.identifierService de Néphrologie et Hémodialyse [CHU HEGP]
hal.structure.identifierAssistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
dc.contributor.authorKARRAS, Alexandre
hal.structure.identifierService de néphrologie [CHU Henri Mondor]
hal.structure.identifierINSERM U955, équipe 21
dc.contributor.authorPOURCINE, Frank
hal.structure.identifierService de Néphrologie CHU TOURS
dc.contributor.authorGATAULT, Philippe
hal.structure.identifierService de néphrologie [CHU Henri Mondor]
hal.structure.identifierINSERM U955, équipe 21
dc.contributor.authorGRIMBERT, Philippe
hal.structure.identifierService de néphrologie [CHU Henri Mondor]
dc.contributor.authorAIT SAHLIA, Nawelle
hal.structure.identifierINSERM U955, équipe 21
hal.structure.identifierGroupe Hospitalier Henri Mondor
dc.contributor.authorMOKTEFI, Anissa
hal.structure.identifierCentre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
dc.contributor.authorDAUGAS, Eric
hal.structure.identifierDepartment of Nephrology, Transplantation and Dialysis, Bordeaux
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRIGOTHIER, Claire
hal.structure.identifierCentre d'Investigation Clinique Henri Mondor [CIC Henri Mondor]
hal.structure.identifierClinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique [CEpiA]
dc.contributor.authorBASTUJI-GARIN, Sylvie
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierINSERM U955, équipe 21
dc.contributor.authorSAHALI, Dil
dc.contributor.authorNATELLA, Pierre
dc.contributor.authorALDIGIER, Jean Claude
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorBATAILLE, Pierre
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorCANAUD, Bernard
hal.structure.identifierService Médecine interne et immunopathologie clinique [CHU Toulouse]
dc.contributor.authorCHAUVEAU, Dominique
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierUnité Médicale de Soins Intensifs
dc.contributor.authorCHOUKROUN, Gabriel
hal.structure.identifierCHRU Brest - Service de Nephrologie [CHU - BREST - Nephrologie]
dc.contributor.authorCORNEC-LEGALL, Emilie
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorDAHAN, Karine
hal.structure.identifierService de transplantation rénale
dc.contributor.authorDELAHOUSSE, Michel
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorDESVAUX, Dominique
dc.contributor.authorDETEIX, Patrice
hal.structure.identifierU542
dc.contributor.authorDURRBACH, Antoine
hal.structure.identifierService de néphrologie
dc.contributor.authorESNAULT, Vincent
hal.structure.identifierPharmacologie des Immunosuppresseurs et de la Transplantation [PIST]
dc.contributor.authorESSIG, Marie
hal.structure.identifierUnivers, Théorie, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) [UTINAM]
dc.contributor.authorFIEVET, Patrick
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
dc.contributor.authorFROUGET, Thierry
hal.structure.identifierService de Néphrologie [Rouen]
dc.contributor.authorGUERROT, Dominique
hal.structure.identifierNouvelles Cibles Pharmacologiques de la Protection Endothéliale et de l'Insuffisance Cardiaque [EnVI]
dc.contributor.authorGODIN, Michel
dc.contributor.authorGONTIERS-PICARD, Annie
dc.contributor.authorGOSSELIN, Morgane
hal.structure.identifierService de Néphrologie
dc.contributor.authorHANROTEL-SALIOU, Catherine
hal.structure.identifierUnité de Nutrition Humaine [UNH]
dc.contributor.authorHENG, Anne-Elisabeth
hal.structure.identifierService Médecine interne et immunopathologie clinique [CHU Toulouse]
dc.contributor.authorHUART, Antoine
dc.contributor.authorHUMBERT, Antoine
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorKOFMAN, Tomek
hal.structure.identifierHôpital Necker - Enfants Malades [AP-HP]
hal.structure.identifierService de néphrologie adultes [CHU Necker]
dc.contributor.authorHUMMEL, Aurélie
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorLANG, Philippe
hal.structure.identifierService de Néphrologie
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierCHRU Brest - Service de Nephrologie [CHU - BREST - Nephrologie]
hal.structure.identifierLymphocytes B, Autoimmunité et Immunothérapies [LBAI]
dc.contributor.authorLEMEUR, Yannick
dc.contributor.authorMALVEZZI, Paolo
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorMATIGNON, Marie
hal.structure.identifierCH Boulogne sur Mer
dc.contributor.authorMESBAH, Rafik
hal.structure.identifierService de Néphrologie et Transplantation
dc.contributor.authorMOULIN, Bruno
dc.contributor.authorMULLER, Sandrine
dc.contributor.authorOLAGNE, Jerome
hal.structure.identifierService de néphrologie et transplantation
dc.contributor.authorPARDON, Agathe
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorPROVÔT, François
hal.structure.identifierService de Néphrologie [CHPC - Site Louis Pasteur]
dc.contributor.authorQUEFFEULOU, Guillaume
dc.contributor.authorPLAISIER, Emmanuelle
hal.structure.identifierService de Néphrologie [Bichat - Claude Bernard]
dc.contributor.authorRAIMBOURG, Quentin
dc.contributor.authorRIEU, Philippe
hal.structure.identifierUniversité Paris Descartes - Faculté de Médecine [UPD5 Médecine]
hal.structure.identifierHôpital Necker - Enfants Malades [AP-HP]
hal.structure.identifierService Néphrologie et transplantation rénale Adultes [CHU Necker]
dc.contributor.authorSTEHLÉ, Thomas
hal.structure.identifierService de médecine interne et néphrologie
dc.contributor.authorVANHILLE, Philippe
dc.contributor.authorBALOUL, Samia
dc.contributor.authorGOUJA, Amel
dc.contributor.authorVIALLETTE, Cedric
dc.date.accessioned2021-06-10T07:05:24Z
dc.date.available2021-06-10T07:05:24Z
dc.date.issued2018-10
dc.identifier.issn0085-2538
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79021
dc.description.abstractEnFirst-line therapy of minimal change nephrotic syndrome (MCNS) in adults is extrapolated largely from pediatric studies and consists of high-dose oral corticosteroids. We assessed whether a low corticosteroid dose combined with mycophenolate sodium was superior to a standard oral corticosteroid regimen. We enrolled 116 adults with MCNS in an open-label randomized controlled trial involving 32 French centers. Participants randomly assigned to the test group (n=58) received low-dose prednisone (0.5 mg/kg/day, maximum 40 mg/day) plus enteric-coated mycophenolate sodium 720 mg twice daily for 24 weeks; those who did not achieve complete remission after week 8 were eligible for a second-line regimen (increase in the prednisone dose to 1 mg/kg/day with or without Cyclosporine). Participants randomly assigned to the control group (n=58) received conventional high-dose prednisone (1 mg/kg/day, maximum 80 mg/day) for 24 weeks. The primary endpoint of complete remission after four weeks of treatment was ascertained in 109 participants, with no significant difference between the test and control groups. Secondary outcomes, including remission after 8 and 24 weeks of treatment, did not differ between the two groups. During 52 weeks of follow-up, MCNS relapsed in 15 participants (23.1%) who had achieved the primary outcome. Median time to relapse was similar in the test and control groups (7.1 and 5.1 months, respectively), as was the incidence of serious adverse events. Five participants died from hemorrhage (n=2) or septic shock (n=3), including 2 participants in the test group and 3 in the control group. Thus, in adult patients, treatment with low-dose prednisone plus enteric-coated mycophenolate sodium was not superior to a standard high-dose prednisone regimen to induce complete remission of MCNS.
dc.language.isoen
dc.publisherNature Publishing Group
dc.subject.enclinical trial
dc.subject.enidiopathic nephrotic syndrome
dc.subject.enmycophenolate
dc.subject.ensteroids
dc.title.enAn open-label randomized controlled trial of low-dose corticosteroid plus enteric-coated mycophenolate sodium versus standard corticosteroid treatment for minimal change nephrotic syndrome in adults (MSN Study)
dc.typeArticle de revue
dc.identifier.doi10.1016/j.kint.2018.07.021
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalKidney International
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-01919505
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01919505v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Kidney%20International&rft.date=2018-10&rft.eissn=0085-2538&rft.issn=0085-2538&rft.au=REMY,%20Philippe&AUDARD,%20Vincent&NATELLA,%20Pierre%20Andr%C3%A9&PELLE,%20Ga%C3%ABlle&DUSSOL,%20Bertrand&rft.genre=article


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