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Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease. A cross-sectional study from the CKD-REIN cohort study

hal.structure.identifierUniversité de Lorraine [UL]
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorSCHWEITZER, ML.
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, B.
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorLEGRAND, K.
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorBRIANÇON, S.
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorJACQUELINET, C.
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, C.
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFOUQUE, D.
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
dc.contributor.authorMASSY, ZA.
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, M.
hal.structure.identifierService de Néphrologie [CHRU Nancy]
dc.contributor.authorFRIMAT, L.
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorAYAV, C.
dc.date2019
dc.date.accessioned2021-06-10T07:05:21Z
dc.date.available2021-06-10T07:05:21Z
dc.date.issued2019
dc.identifier.issn0962-9343
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79019
dc.description.abstractEnPurpose: To evaluate the association between obesity phenotypes and health-related quality of life (HRQoL) in non-dialysis-dependent CKD patients.Methods: Data from the national CKD-REIN cohort which included 3033 patients with stage 3-4 CKD were used. Patients were divided into three groups: non-obese (NO) patients (BMI < 30 kg/m2), metabolically healthy obese (MHO) (BMI ≥ 30 kg/m2 and ≤ 1 criterion NCEP/ATP III), and metabolically unhealthy obese (MUO) (BMI ≥ 30 kg/m2 and ≥ 2 criteria NCEP/ATP III). HRQoL was measured by the KDQOL-36™ which comprised three disease-specific dimensions: symptoms, effects, and burden and two summaries scores: physical (PCS) and mental (MCS). We used a mixed effect model with adjustment on sociodemographic characteristics and comorbidities.Results: A total of 2693 patients completed the self-administered questionnaires. MHO patients accounted for 3.4% of the cohort and for 12% of obese patients. In the NO group, average HRQoL scores were 77.2 ± 15.9 for symptoms, 83.5 ± 16.5 for effects, 76.8 ± 22.7 for burden, 43.5 ± 9.7 for PCS, and 47.9 ± 7.0 for MCS. In the multivariate analysis, scores were similar in MHO and NO patients, but significantly different with those in MUO patients: symptoms (- 0.7; p = 0.71 vs. - 3.0; p = 0.0025), effects (+ 1.2; p = 0.57 vs. - 4.3; p < 0.0001), burden (+ 2.7; p = 0.31 vs. - 3.6; p = 0.0031), and PCS (- 0.6; p = 0.58 vs. - 4.3; p < 0.0001). MCS was not associated with obesity phenotypes.Conclusions: This study demonstrated an association between obesity phenotypes and QoL in non-dialysis-dependent CKD patients. MUO patients had worse QoL than NO and MHO patients even after adjustment on comorbidities.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enChronic kidney disease
dc.subject.enCKD-REIN cohort
dc.subject.enQuality of life
dc.subject.enObesity
dc.title.enObesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease. A cross-sectional study from the CKD-REIN cohort study
dc.typeArticle de revue
dc.identifier.doi10.1007/s11136-019-02110-2
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalQuality of Life Research
bordeaux.page1873-1883
bordeaux.volume28
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue7
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-01981924
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01981924v1
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