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Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease. A cross-sectional study from the CKD-REIN cohort study
hal.structure.identifier | Université de Lorraine [UL] | |
hal.structure.identifier | Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC] | |
dc.contributor.author | SCHWEITZER, ML. | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
dc.contributor.author | STENGEL, B. | |
hal.structure.identifier | Maladies chroniques, santé perçue, et processus d'adaptation [APEMAC] | |
hal.structure.identifier | Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC] | |
dc.contributor.author | LEGRAND, K. | |
hal.structure.identifier | Maladies chroniques, santé perçue, et processus d'adaptation [APEMAC] | |
dc.contributor.author | BRIANÇON, S. | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
hal.structure.identifier | Agence de la biomédecine [Saint-Denis la Plaine] | |
dc.contributor.author | JACQUELINET, C. | |
hal.structure.identifier | Service de Néphrologie-transplantation-dialyse [Bordeaux] | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | COMBE, C. | |
hal.structure.identifier | Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS] | |
hal.structure.identifier | Cardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN] | |
dc.contributor.author | FOUQUE, D. | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
hal.structure.identifier | Service Néphrologie/Dialyse [AP-HP Ambroise-Paré] | |
dc.contributor.author | MASSY, ZA. | |
hal.structure.identifier | Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS] | |
hal.structure.identifier | Cardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN] | |
dc.contributor.author | LAVILLE, M. | |
hal.structure.identifier | Service de Néphrologie [CHRU Nancy] | |
dc.contributor.author | FRIMAT, L. | |
hal.structure.identifier | Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC] | |
dc.contributor.author | AYAV, C. | |
dc.date | 2019 | |
dc.date.accessioned | 2021-06-10T07:05:21Z | |
dc.date.available | 2021-06-10T07:05:21Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0962-9343 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/79019 | |
dc.description.abstractEn | Purpose: To evaluate the association between obesity phenotypes and health-related quality of life (HRQoL) in non-dialysis-dependent CKD patients.Methods: Data from the national CKD-REIN cohort which included 3033 patients with stage 3-4 CKD were used. Patients were divided into three groups: non-obese (NO) patients (BMI < 30 kg/m2), metabolically healthy obese (MHO) (BMI ≥ 30 kg/m2 and ≤ 1 criterion NCEP/ATP III), and metabolically unhealthy obese (MUO) (BMI ≥ 30 kg/m2 and ≥ 2 criteria NCEP/ATP III). HRQoL was measured by the KDQOL-36™ which comprised three disease-specific dimensions: symptoms, effects, and burden and two summaries scores: physical (PCS) and mental (MCS). We used a mixed effect model with adjustment on sociodemographic characteristics and comorbidities.Results: A total of 2693 patients completed the self-administered questionnaires. MHO patients accounted for 3.4% of the cohort and for 12% of obese patients. In the NO group, average HRQoL scores were 77.2 ± 15.9 for symptoms, 83.5 ± 16.5 for effects, 76.8 ± 22.7 for burden, 43.5 ± 9.7 for PCS, and 47.9 ± 7.0 for MCS. In the multivariate analysis, scores were similar in MHO and NO patients, but significantly different with those in MUO patients: symptoms (- 0.7; p = 0.71 vs. - 3.0; p = 0.0025), effects (+ 1.2; p = 0.57 vs. - 4.3; p < 0.0001), burden (+ 2.7; p = 0.31 vs. - 3.6; p = 0.0031), and PCS (- 0.6; p = 0.58 vs. - 4.3; p < 0.0001). MCS was not associated with obesity phenotypes.Conclusions: This study demonstrated an association between obesity phenotypes and QoL in non-dialysis-dependent CKD patients. MUO patients had worse QoL than NO and MHO patients even after adjustment on comorbidities. | |
dc.language.iso | en | |
dc.publisher | Springer Verlag | |
dc.subject.en | Chronic kidney disease | |
dc.subject.en | CKD-REIN cohort | |
dc.subject.en | Quality of life | |
dc.subject.en | Obesity | |
dc.title.en | Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease. A cross-sectional study from the CKD-REIN cohort study | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1007/s11136-019-02110-2 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
bordeaux.journal | Quality of Life Research | |
bordeaux.page | 1873-1883 | |
bordeaux.volume | 28 | |
bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
bordeaux.issue | 7 | |
bordeaux.institution | CNRS | |
bordeaux.institution | INSERM | |
bordeaux.institution | CHU de Bordeaux | |
bordeaux.institution | Institut Bergonié | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01981924 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01981924v1 | |
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