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Perceived Health and Quality of Life in Patients With CKD, Including Those With Kidney Failure: Findings From National Surveys in France

hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorLEGRAND, Karine
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSPEYER, Elodie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Bénédicte
hal.structure.identifierService de Néphrologie [CHRU Nancy]
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorNGUEYON SIME, Willy
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorMASSY, Ziad
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFOUQUE, Denis
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorJACQUELINET, Christian
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorDURAND, Anne Claire
hal.structure.identifierCHU Rouen
dc.contributor.authorEDET, Stéphane
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorGENTILE, Stéphanie
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorBRIANCON, Serge
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorAYAV, Carole
dc.date.accessioned2021-06-10T07:04:46Z
dc.date.available2021-06-10T07:04:46Z
dc.date.issued2019-12
dc.identifier.issn0272-6386
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78994
dc.description.abstractEnRATIONALE & OBJECTIVE: Health-related quality of life (HRQoL) is a major outcome measure increasingly used in patients with chronic kidney disease (CKD). We evaluated the association between different stages of CKD and the physical and mental health domains of HRQoL.STUDY DESIGN: Cross-sectional study.SETTING & PARTICIPANTS: 2,693 outpatients with moderate (stage 3, estimated glomerular filtration rate [eGFR], 30-60mL/min/1.73m2) or advanced (stages 4-5, estimated glomerular filtration rate<30mL/min/1.73m2, not on kidney replacement therapy [KRT]) CKD under the care of a nephrologist at 1 of 40 nationally representative facilities, 1,658 patients with a functioning kidney transplant, 1,251 patients on maintenance dialysis randomly selected from the national Renal Epidemiology and Information Network registry, and 20,574 participants in the French Decennial Health Survey, representative of the general population.PREDICTOR: Severity of kidney disease (moderate CKD, advanced CKD, maintenance dialysis as KRT, and functioning kidney transplant as KRT), compared with a sample of the general population.OUTCOMES: HRQoL scores assessed using the Medical Outcomes Study 36-Item Short Form Health Survey or the Kidney Disease Quality of Life 36 scale.ANALYTICAL APPROACH: Age- and sex-standardized (to the general population) prevalence of poor or fair health status was estimated for each study kidney disease group. Analysis of variance was used to estimate adjusted differences in mean physical and mental health scores between the kidney disease subgroups and the general population.RESULTS: Mean age was 67.2±12.6 (SD) years for patients with non-KRT-requiring CKD, 69.3±17.7 years for dialysis patients, and 55.3±14.2 years for those with functioning kidney transplants; 60% were men. Age- and sex-standardized health status was perceived as fair or poor in 27% of those with moderate CKD,>40% of those with advanced CKD or receiving dialysis, 12% with a functioning transplant, and 3% of the general population sample. HRQoL physical scores (adjusted for age, sex, education, obesity, and diabetes) were significantly lower in patients in all CKD subgroups than in the general population. For patients receiving dialysis, the magnitude of the difference in physical score versus the general population exceeded 4.5 points, the minimal clinically important difference for this score in this study; for both kidney transplant recipients and patients with advanced CKD, the magnitude of the difference was close to this threshold. For mental score, only dialysis patients had a score that differed from that of the general population by more than the minimal clinically important difference.LIMITATIONS: Cross-sectional study design for each subpopulation.CONCLUSIONS: This study highlights the degree to which perceived physical health is lower in the setting of CKD than in the general population, even in the absence of kidney failure, and calls for greater attention to CKD-related quality of life.
dc.language.isoen
dc.publisherElsevier
dc.subject.enkidney transplant patients
dc.subject.enkidney failure
dc.subject.enhealth-related quality of life (HRQoL)
dc.subject.enrenal replacement therapy (RRT)
dc.subject.ensurvey data
dc.subject.enpatient-reported outcomes (PROs)
dc.subject.enpatient well-being
dc.subject.enhealth status
dc.subject.enend-stage renal disease (ESRD)
dc.subject.endialysis patients
dc.subject.enChronic kidney disease (CKD)
dc.subject.ensymptom burden
dc.title.enPerceived Health and Quality of Life in Patients With CKD, Including Those With Kidney Failure: Findings From National Surveys in France
dc.typeArticle de revue
dc.identifier.doi10.1053/j.ajkd.2019.08.026
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalAmerican Journal of Kidney Diseases
bordeaux.page868-878
bordeaux.volume75
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue6
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02438433
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02438433v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=American%20Journal%20of%20Kidney%20Diseases&amp;rft.date=2019-12&amp;rft.volume=75&amp;rft.issue=6&amp;rft.spage=868-878&amp;rft.epage=868-878&amp;rft.eissn=0272-6386&amp;rft.issn=0272-6386&amp;rft.au=LEGRAND,%20Karine&amp;SPEYER,%20Elodie&amp;STENGEL,%20B%C3%A9n%C3%A9dicte&amp;FRIMAT,%20Luc&amp;NGUEYON%20SIME,%20Willy&amp;rft.genre=article


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