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Impact of age on cardiovascular drug use in patients with chronic kidney disease

hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
dc.contributor.authorVILLAIN, Cédric
hal.structure.identifierCHU Amiens-Picardie
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
dc.contributor.authorLIABEUF, Sophie
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierService de néphrologie
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFOUQUE, Denis
hal.structure.identifierService de Néphrologie [CHRU Nancy]
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorJACQUELINET, Christian
hal.structure.identifierService de Néphrologie [Lyon]
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorBRIANÇON, Serge
hal.structure.identifierArbor Research Collaborative for Health
dc.contributor.authorPISONI, Ronald
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
hal.structure.identifierService de cardiologie et maladies vasculaires [CHU Ambroise Paré]
dc.contributor.authorMANSENCAL, Nicolas
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
dc.contributor.authorSTENGEL, Bénédicte
hal.structure.identifierÉpidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)]
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
dc.contributor.authorMASSY, Ziad
dc.date.accessioned2021-06-10T07:04:31Z
dc.date.available2021-06-10T07:04:31Z
dc.date.issued2020-04-01
dc.identifier.issn2048-8505
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78980
dc.description.abstractEnBackground: Elderly patients with chronic kidney disease (CKD) are often excluded from clinical trials; this may affect their use of essential drugs for cardiovascular complications. We sought to assess the impact of age on cardiovascular drug use in elderly patients with CKD.Methods: We used baseline data from the Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort including 3033 adult patients with CKD Stages 3 and 4. We studied the use of recommended drugs for coronary artery disease (CAD), stroke and atrial fibrillation by age, after adjusting for socio-demographic and clinical conditions.Results: The patients' mean age was 66.8 years (mean estimated glomerular filtration rate 32.9 mL/min/1.73 m2). The prevalence of CAD was 24.5% [81.3% receiving antiplatelet agents, 75.6% renin-angiotensin system (RAS) blockers, 65.4% β-blockers and 81.3% lipid-lowering therapy], that of stroke 10.0% (88.8% receiving antithrombotic drugs) and that of atrial fibrillation 11.1% (69.5% receiving oral anticoagulants). Compared with patients aged <65 years, older age (≥65 years) was associated with greater use of antithrombotic drugs in stroke [adjusted odds ratio (aOR) (95% confidence interval) = 2.83 (1.04-7.73) for patients aged (75-84 years)] and less use of RAS blockers [aOR = 0.39 (0.16-0.89) for patients aged ≥85 years], β-blockers [aOR = 0.31 (0.19-0.53) for patients aged 75-84 years] and lipid-lowering therapy [aOR = 0.39 (0.15-1.02) for patients aged ≥85 years, P for trend = 0.01] in CAD. Older age was not associated with less use of antiplatelet agents in CAD or oral anticoagulants in atrial fibrillation.Conclusions: In patients with CKD, older age per se was not associated with the underuse of antithrombotic drugs but was for other major drugs, with a potential impact on cardiovascular outcomes.
dc.language.isoen
dc.publisherOxford University Press
dc.subject.enatrial fibrillation
dc.subject.enchronic kidney disease
dc.subject.encoronary artery disease
dc.subject.enelderly
dc.subject.enstroke
dc.subject.enunderuse
dc.title.enImpact of age on cardiovascular drug use in patients with chronic kidney disease
dc.typeArticle de revue
dc.identifier.doi10.1093/ckj/sfz063
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalClinical Kidney Journal
bordeaux.page199-207
bordeaux.volume13
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue2
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02572053
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02572053v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Clinical%20Kidney%20Journal&amp;rft.date=2020-04-01&amp;rft.volume=13&amp;rft.issue=2&amp;rft.spage=199-207&amp;rft.epage=199-207&amp;rft.eissn=2048-8505&amp;rft.issn=2048-8505&amp;rft.au=VILLAIN,%20C%C3%A9dric&amp;LIABEUF,%20Sophie&amp;METZGER,%20Marie&amp;COMBE,%20Christian&amp;FOUQUE,%20Denis&amp;rft.genre=article


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