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Alendronate or Zoledronic acid do not impair wound healing after tooth extraction in postmenopausal women with osteoporosis

hal.structure.identifierUniversité de Nantes - UFR Odontologie [UFR Odonto]
hal.structure.identifierRegenerative Medicine and Skeleton [RMeS]
dc.contributor.authorLESCLOUS, Philippe
hal.structure.identifierRegenerative Medicine and Skeleton [RMeS]
hal.structure.identifierUniversité de Nantes - UFR Odontologie [UFR Odonto]
dc.contributor.authorCLOITRE, Alexandra
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCATROS, Sylvain
hal.structure.identifierNeuro-Dol [Neuro-Dol]
dc.contributor.authorDEVOIZE, Laurent
hal.structure.identifierService d'Odontologie [CHRU Lille]
dc.contributor.authorLOUVET, Béatrice
hal.structure.identifierService de chirurgie plastique et maxillofaciale
dc.contributor.authorCHÂTEL, Cécile
hal.structure.identifierCIC - Mère Enfant Necker Cochin Paris Centre [CIC 1419]
dc.contributor.authorFOISSAC, Frantz
hal.structure.identifierCentre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
dc.contributor.authorROUX, Christian
dc.date.accessioned2021-06-10T07:04:30Z
dc.date.available2021-06-10T07:04:30Z
dc.date.issued2020-08
dc.identifier.issn8756-3282
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78978
dc.description.abstractEnBackground: Bisphosphonates (BPs) are widely used for the prevention or treatment of osteoporosis. One of the most serious complications associated with BPs is medication-related osteonecrosis of the jaw (MRONJ) but its incidence in patients with osteoporosis is very low ranging from 0.001-0.15%. A major predisposing factor for MRONJ is tooth extraction (TE). Controversies persist about the influence of current BP therapy regarding socket healing after TE. The aims of this study were to investigate prospectively, (i) alveolar bone healing, i.e., filling of the bony socket by new bone and (ii) mucosal healing, i.e., closure of the overlying mucosa, after TE in women receiving current BP therapy for the prevention or the treatment of postmenopausal osteoporosis. Methods: Women with osteoporosis under current treatment with BPs (BP+ group) or other anti-osteoporotic medications (BP-group) undergoing single TE were included in this study. No antibiotic prophylaxis was prescribed solely for the BP therapy, but antibiotic treatment may have been required for local infectious conditions. Chlorohexidine mouthwashes were systematically prescribed in all study patients for one week after TE. New bone height (NBH) and rate of socket filling (RSF) were recorded using intraoral standardized radiographs one month and 3 months after TE (T30 and T90 respectively). The closure of the overlying mucosa was assessed by measuring the wound extent with an electronic caliper at 1 week and at 1 month after TE (T7 and T30 respectively). Results: At T30, NBH was not statistically different between the BP+ and BP-groups (p = .76). At T90, more than a twofold in NBH increase was recorded for both groups with no statistically significant difference between them (p = .76). At T30 and T90, RSF was similar in both groups (p = .58 and p = .32 respectively). More than a twofold RSF increase was founded between T30 and T90 in both groups. No demographic or BPs-related factors were correlated with the RSF at T90. At T7, the mucosa wound extent was reduced by more than twofold with no statistically significant difference between both groups (p = .80). At this time, mucosa healing was achieved in 11.9% of the BP+ group and 10% of the BP-group (p = .99). At T30, mucosal healing was achieved in all patients but two, and at T90 it was achieved in all patients. Conclusion: This study provides new insights into bone and mucosal healing in patients with osteoporosis taking BPs after TE. In this population, TE can be managed successfully with an appropriate surgical protocol and without discontinuation of BP treatment.
dc.language.isoen
dc.publisherElsevier
dc.subject.enBisphosphonates
dc.subject.enOsteonecrosis of the jaw
dc.subject.enOsteoporosis
dc.subject.enTooth extraction
dc.subject.enWound healing.
dc.title.enAlendronate or Zoledronic acid do not impair wound healing after tooth extraction in postmenopausal women with osteoporosis
dc.typeArticle de revue
dc.identifier.doi10.1016/j.bone.2020.115412
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Rhumatologie et système ostéo-articulaire
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Gériatrie et gérontologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Anatomie, Histologie, Anatomopathologie [q-bio.TO]
bordeaux.journalBONE
bordeaux.volume115412
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02613524
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02613524v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BONE&rft.date=2020-08&rft.volume=115412&rft.eissn=8756-3282&rft.issn=8756-3282&rft.au=LESCLOUS,%20Philippe&CLOITRE,%20Alexandra&CATROS,%20Sylvain&DEVOIZE,%20Laurent&LOUVET,%20B%C3%A9atrice&rft.genre=article


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