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Cartography of the mechanical properties of the human amniotic membrane

hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGREMARE, Agathe
hal.structure.identifierUniversité de Cergy Pontoise [UCP]
dc.contributor.authorJEAN-GILLES, Sarah
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorMUSQUI, Pauline
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMAGNAN, Laure
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorTORRES, Yoann
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFENELON, Mathilde
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBRUN, Stéphanie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorL’HEUREUX, Nicolas
dc.date.accessioned2021-06-10T07:04:10Z
dc.date.available2021-06-10T07:04:10Z
dc.date.issued2019-11
dc.identifier.issn1751-6161
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78957
dc.description.abstractEnBecause of its low immunogenicity, biological properties, and high availability, the Human Amniotic Membrane (HAM) is widely used in the clinic and in tissue engineering research. However, while its biological characteristics are well described, its mechanical properties remain understudied especially in terms of inter- and intra-HAM variability. To guide bioengineers in the use of this natural biomaterial, a detailed cartography of the HAM's mechanical properties was performed. Maximal force (Fmax) and strain at break (Smax) were identified as the relevant mechanical criteria for this study after a combined analysis of histological sections, thickness measurements after dehydration, and uniaxial tensile tests. Eight HAMs were studied by mechanical cartography using a standardized cutting protocol and sampling pattern. On average, 103 ± 10 samples were retrieved and tested per HAM. Intra-tissue variability highlighted the fact that there were two mechanically distinct areas (placental and peripheral) in each HAM. For all HAMs, placental HAM was significantly stronger by 82 ± 45% and more stretchable by 19 ± 6% than their peripheral counterparts. Our results also demonstrated that placental, but not peripheral, HAM presented isotropic mechanical properties. Thus, placental HAM can be a raw material of choice that could be favored especially in the development of tissue engineering products where mechanical properties play a key role.
dc.language.isoen
dc.publisherElsevier
dc.subject.enHuman amnion
dc.subject.enMapping
dc.subject.enMechanical properties
dc.subject.enNatural biomaterial
dc.subject.enTissue engineering.
dc.title.enCartography of the mechanical properties of the human amniotic membrane
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jmbbm.2019.07.007
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalJournal of the mechanical behavior of biomedical materials
bordeaux.page18-26
bordeaux.volume99
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870489
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870489v1
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