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Human amniotic membrane for guided bone regeneration of calvarial defects in mice

hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierPôle d’Odontologie et de Santé Buccale [CHU Bordeaux]
dc.contributor.authorFENELON, Mathilde
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCHASSANDE, Olivier
IDREF: 034414975
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorKALISKY, Jérome
hal.structure.identifierService de Chirurgie Orthopédique Traumatologique et Plastique [Besançon]
dc.contributor.authorGINDRAUX, Florelle
hal.structure.identifierService de Gynécologie-Obstétrique [CHU Bordeaux]
dc.contributor.authorBRUN, Stéphanie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
hal.structure.identifierEtablissement Français du Sang Nouvelle Aquitaine [Bordeaux] [EFS Bordeaux Nouvelle Aquitaine]
dc.contributor.authorIVANOVIC, Zoran
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierPôle d’Odontologie et de Santé Buccale [CHU Bordeaux]
dc.contributor.authorFRICAIN, Jean-Christophe
ORCID: 0000-0001-7855-6437
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBOIZIAU, Claudine
ORCID: 0000-0002-0475-2571
IDREF: 85228370
dc.date.accessioned2021-06-10T07:04:06Z
dc.date.available2021-06-10T07:04:06Z
dc.date.issued2018-06
dc.identifier.issn0957-4530
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78953
dc.description.abstractEnDue to its biological properties, human amniotic membrane (hAM) is widely studied in the field of tissue engineering and regenerative medicine. hAM is already very attractive for wound healing and it may be helpful as a support for bone regeneration. However, few studies assessed its potential for guided bone regeneration (GBR). The purpose of the present study was to assess the potential of the hAM as a membrane for GBR. In vitro, cell viability in fresh and cryopreserved hAM was assessed. In vivo, we evaluated the impact of fresh versus cryopreserved hAM, using both the epithelial or the mesenchymal layer facing the defect, on bone regeneration in a critical calvarial bone defect in mice. Then, the efficacy of cryopreserved hAM associated with a bone substitute was compared to a collagen membrane currently used for GBR. In vitro, no statistical difference was observed between the conditions concerning cell viability. Without graft material, cryopreserved hAM induced more bone formation when the mesenchymal layer covered the defect compared to the defect left empty. When associated with a bone substitute, such improved bone repair was not observed. These preliminary results suggest that cryopreserved hAM has a limited potential for GBR.
dc.language.isoen
dc.publisherSpringer Verlag
dc.title.enHuman amniotic membrane for guided bone regeneration of calvarial defects in mice
dc.typeArticle de revue
dc.identifier.doi10.1007/s10856-018-6086-9
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalJournal of Materials Science: Materials in Medicine
bordeaux.page78
bordeaux.volume29
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue6
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870572
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870572v1
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