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Topical rapamycin versus betamethasone dipropionate ointment for treating oral erosive lichen planus: a randomized, double‐blind, controlled study

hal.structure.identifierService de dermatologie (CHRU de Tours)
hal.structure.identifierInfectiologie et Santé Publique [UMR ISP]
dc.contributor.authorSAMIMI, Mahtab
dc.contributor.authorLE GOUGE, A.
hal.structure.identifierU1035 Centre de R ef erence pour les Maladies Rares de la Peau, Service de Dermatologie Adulte et Pédiatrique
dc.contributor.authorBORALEVI, F.
hal.structure.identifierCentre méditerranéen de médecine moléculaire [C3M]
dc.contributor.authorPASSERON, T.
hal.structure.identifierHopital Saint-Louis [AP-HP] [AP-HP]
dc.contributor.authorPASCAL, F.
hal.structure.identifierService de dermatologie (CHU de Reims)
dc.contributor.authorBERNARD, P.
dc.contributor.authorAGBO‐GODEAU, S
hal.structure.identifierService de dermatologie (CHRU de Tours)
dc.contributor.authorLEDUCQ, S.
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, JC
hal.structure.identifierService de dermatologie (CHRU de Tours)
dc.contributor.authorVAILLANT, L.
dc.contributor.authorFRANCÈS, C.
dc.date.accessioned2021-06-10T07:03:31Z
dc.date.available2021-06-10T07:03:31Z
dc.date.issued2020-10
dc.identifier.issn0926-9959
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78921
dc.description.abstractEnBackground Although superpotent topical corticosteroids are the first-line treatment for oral erosive lichen planus (OELP), topical rapamycin was found efficient in a previous case series.Objectives To compare the efficacy and safety of topical rapamycin and betamethasone dipropionate ointment for OELP in a randomized, double-blind trial.Methods Patients were randomized to receive treatment with betamethasone dipropionate ointment 0.05% in Orabase(R) or topical rapamycin solution (1 mg/mL) on lesions twice daily for 3 months, followed by 3 months of observation. The primary outcome was clinical remission after 3 months of treatment. Secondary outcomes were clinical remission after 1 and 2 months, reduced oral pain and reduced impact on food intake after 3 months, clinical recurrence after treatment withdrawal, and adverse events.Results During a 4-year period, 76 patients were randomized and 75 received treatment (rapamycin, n = 39; betamethasone, n = 36). At 3 months, 39.4% of patients with betamethasone and 27.3% with rapamycin showed clinical remission (odds ratio 0.68, 95% CI [0.24; 1.89]; P = 0.46). Rates of remission after 1 and 2 months, reduction in pain and impact on food intake after 3 months, were higher with betamethasone than rapamycin. Recurrence of oral erosions was similar between groups. Adverse events occurred in 43.6% of patients with rapamycin (mostly burning sensation, impaired taste) and 27.8% with betamethasone (mostly oral candidiasis).Conclusion Although the study was limited by insufficient recruitment, we did not find any superiority of topical rapamycin over betamethasone dipropionate ointment for OELP. Given the rapid remission and pain improvement in the betamethasone group, it appears that superpotent topical corticosteroids should remain the first-line treatment for OELP.
dc.language.isoen
dc.publisherWiley
dc.title.enTopical rapamycin versus betamethasone dipropionate ointment for treating oral erosive lichen planus: a randomized, double‐blind, controlled study
dc.typeArticle de revue
dc.identifier.doi10.1111/jdv.16324
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Dermatologie
bordeaux.journalJournal of the European Academy of Dermatology and Venereology
bordeaux.page2384-2391
bordeaux.volume34
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue10
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02972478
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02972478v1
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