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Urinary Sodium-to-Potassium Ratio and Blood Pressure in CKD

hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorALENCAR DE PINHO, Natalia
hal.structure.identifierInstitut de Recherche en Sciences de la Santé [IRSS]
dc.contributor.authorKABORÉ, Jean K.
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorLANGE, Céline
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorJACQUELINET, Christian
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFOUQUE, Denis P.
hal.structure.identifierService de Néphrologie [CHRU Nancy]
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierCentre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
dc.contributor.authorAYAV, Carole
hal.structure.identifierArbor Research Collaborative for Health
dc.contributor.authorROBINSON, Bruce M.
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorDRUEKE, Tilman Bernhard
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierHôpital Ambroise Paré [AP-HP]
dc.contributor.authorMASSY, Ziad André
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Bénédicte Né Dicte
dc.contributor.authorHANNEDOUCHE, Thierry P.
dc.contributor.authorMOULIN, Bruno
dc.contributor.authorMAILLIEZ, Sébastien
dc.contributor.authorLEBRUN, Gaétan
dc.contributor.authorMAGNANT, Éric
dc.contributor.authorCHOUKROUN, Gabriel
dc.contributor.authorDEROURE, Benjamin
dc.contributor.authorLACRAZ, Adeline
dc.contributor.authorLAMBREY, Guy
dc.contributor.authorBOURDENX, Jean Philippe
dc.contributor.authorESSIG, Marie
dc.contributor.authorLOBBEDEZ, Thierry
dc.contributor.authorAZAR, Raymond
dc.contributor.authorSEKHRI, Hacène
dc.contributor.authorSMATI, Mustafa
dc.contributor.authorJAMALI, Mohamed
dc.contributor.authorKLEIN, Alexandre
dc.contributor.authorDELAHOUSSE, Michel
dc.contributor.authorMARTIN, Séverine
dc.contributor.authorLANDRU, Isabelle
dc.contributor.authorTHERVET, Éric
dc.contributor.authorLANG, Philippe
dc.contributor.authorBELENFANT, Xavier
dc.contributor.authorURENA, Pablo
dc.contributor.authorVELA, Carlos Gustavo
dc.contributor.authorCHAUVEAU, Dominique
dc.contributor.authorPANESCU, Victor
dc.contributor.authorNOEL, Christian
dc.contributor.authorGLOWACKI, François
dc.contributor.authorHOFFMANN, Maxime
dc.contributor.authorHOURMANT, Maryvonne H.
dc.contributor.authorBESNIER, Dominique P.
dc.contributor.authorTESTA, Angelo
dc.contributor.authorKUENTZ, François
dc.contributor.authorZAOUI, Philippe M.
dc.contributor.authorCHAZOT, Charles
dc.contributor.authorJUILLARD, Laurent
hal.structure.identifierCentre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
dc.contributor.authorBURTEY, Stéphane
dc.contributor.authorKELLER, Adrien
dc.contributor.authorKAMAR, Nassim
dc.date.accessioned2021-06-10T07:03:21Z
dc.date.available2021-06-10T07:03:21Z
dc.date.issued2020-05-18
dc.identifier.issn2468-0249
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78911
dc.description.abstractEnIntroduction: In the general population, urinary sodium-to-potassium (uNa/K) ratio associates more strongly with high blood pressure (BP) than either urinary sodium or potassium alone. Whether this is also the case among patients with chronic kidney disease (CKD) is unknown. Methods: We studied the associations of spot urine sodium-to-creatinine (uNa/Cr), potassium-to-creatinine (uK/Cr), and uNa/K ratios with a single office BP reading in 1660 patients with moderate to severe CKD at inclusion in the CKD-REIN cohort. Results: Patients' median age was 68 (interquartile range [IQR], 59–76) years; most were men (65%), had moderate CKD (57%), and albuminuria (72%). Mean systolic and diastolic BP was 142/78 mm Hg. Spot uNa/Cr and uNa/K ratios were positively associated with systolic, mean arterial, and pulse pressures. The mean adjusted difference in systolic BP between the highest and the lowest quartile (Q4 vs. Q1) was 4.24 (95% confidence interval [CI], 1.53–6.96) mm Hg for uNa/Cr and 4.79 (95% CI, 2.18–7.39) mm Hg for uNa/K. Quartiles of spot uK/Cr were not associated with any BP index. The higher the quartile of uNa/K, the higher the prevalence ratio of uncontrolled (Q4 vs. Q1, 1.43; 95% CI, 1.19–1.72) or apparently treatment-resistant hypertension (Q4 vs. Q1, 1.35; 95% CI, 1.14–1.60). Findings were consistent in a subset of 803 individuals with 2 BP readings. Conclusion: In patients with CKD, higher urinary sodium excretion is associated with higher BP, but unlike in general population, lower potassium excretion is not. Urinary Na/K does not add significant value in assessing high BP risk, except perhaps for hypertension control assessment.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enblood pressure
dc.subject.enchronic kidney disease
dc.subject.enpotassium
dc.subject.ensalt
dc.subject.ensodium
dc.title.enUrinary Sodium-to-Potassium Ratio and Blood Pressure in CKD
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ekir.2020.05.025
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie
bordeaux.journalKidney International Reports
bordeaux.page1240-1250
bordeaux.volume5
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue8
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02938426
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02938426v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Kidney%20International%20Reports&rft.date=2020-05-18&rft.volume=5&rft.issue=8&rft.spage=1240-1250&rft.epage=1240-1250&rft.eissn=2468-0249&rft.issn=2468-0249&rft.au=ALENCAR%20DE%20PINHO,%20Natalia&KABOR%C3%89,%20Jean%20K.&LAVILLE,%20Maurice&METZGER,%20Marie&LANGE,%20C%C3%A9line&rft.genre=article


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