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Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors

hal.structure.identifierHôpital Pellegrin
dc.contributor.authorDUMAS DE LA ROQUE, C.
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierCIC Bordeaux
dc.contributor.authorPREZELIN-REYDIT, Mathilde
hal.structure.identifierHôpital Pellegrin
dc.contributor.authorVERMOREL, A.
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLEPREUX, S.
dc.contributor.authorDEMINIERE, C.
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, C.
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRIGOTHIER, C.
dc.date.accessioned2021-06-10T07:03:20Z
dc.date.available2021-06-10T07:03:20Z
dc.date.issued2018
dc.identifier.issn2077-0383
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78910
dc.description.abstractEnThere are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. We studied 165 patients with idiopathic nephrotic syndrome; 97 with MCD and 68 with FSGS. In the MCD cohort, 91.7% of patients were treated with corticosteroids for a median total duration of 13 months. During 45 months of follow-up, 92.8% of patients achieved remission and 45.5% experienced relapse. In this cohort, 5% of patients experienced terminal kidney disease. With respect to FSGS patients, 51.5% were treated with corticosteroids for a median total duration of 15 months. During 66 months of follow-up, 73.5% of patients achieved remission and 20% experienced relapse. In this cohort, 26.5% of patients experienced terminal kidney disease. No statistical association was observed between clinical and biological initial presentation and relapse occurrence. This study describes the characteristics of a cohort of patients with the nephrotic idiopathic syndromes of MCD and FSGS from the time of renal biopsy and throughout follow-up.
dc.language.isoen
dc.publisherMDPI
dc.subject.enidiopathic nephrotic syndrome
dc.subject.enminimal change disease
dc.subject.enfocal segmental glomerulosclerosis
dc.subject.enrelapse
dc.subject.enrisk factors
dc.subject.encomplication
dc.title.enIdiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors
dc.typeArticle de revue
dc.identifier.doi10.3390/jcm7090265
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalJournal of Clinical Medicine
bordeaux.page265
bordeaux.volume7
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue9
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-03164706
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03164706v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Medicine&rft.date=2018&rft.volume=7&rft.issue=9&rft.spage=265&rft.epage=265&rft.eissn=2077-0383&rft.issn=2077-0383&rft.au=DUMAS%20DE%20LA%20ROQUE,%20C.&PREZELIN-REYDIT,%20Mathilde&VERMOREL,%20A.&LEPREUX,%20S.&DEMINIERE,%20C.&rft.genre=article


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