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Altered nanofeature size dictates stem cell differentiation

dc.contributor.authorZOUANI O, Farouk
dc.contributor.authorCHANSEAU, Christel
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBROUILLAUD, Brigitte
dc.contributor.authorBARIELLE, Reine
dc.contributor.authorDELIANE, Florent
dc.contributor.authorFOULC, Marie-Pierre
hal.structure.identifierInstitut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM ICMMM]
dc.contributor.authorMEHDI, Ahmad
dc.contributor.authorDURRIEU, Marie-Christine
dc.date.accessioned2021-06-10T07:03:15Z
dc.date.available2021-06-10T07:03:15Z
dc.date.issued2012-02-02
dc.identifier.issn0021-9533
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78904
dc.description.abstractEnThe differentiation of stem cells can be modulated by physical factors such as the micro- and nano-topography of the extracellular matrix. One important goal in stem cell research is to understand the concept that directs differentiation into a specific cell lineage in the nanoscale environment. Here, we demonstrate that such paths exist by controlling only the micro- and nano-topography of polymer surfaces. Altering the depth (on a nanometric scale) of micro-patterned surface structures allowed increased adhesion of human mesenchymal stem cells (hMSCs) with specific differentiation into osteoblasts, in the absence of osteogenic medium. Small (10 nm) depth patterns promoted cell adhesion without noticeable differentiation, whereas larger depth patterns (100 nm) elicited a collective cell organization, which induced selective differentiation into osteoblast-like cells. This latter response was dictated by stress through focal-adhesion-induced reorganization of F-actin filaments. The results have significant implications for understanding the architectural effects of the in vivo microenvironment and also for the therapeutic use of stem cells.
dc.language.isoen
dc.publisherCompany of Biologists
dc.typeArticle de revue
dc.identifier.doi10.1242/jcs.093229
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalJournal of Cell Science
bordeaux.page1217-1224
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue125
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-00683959
hal.version1
dc.title.itAltered nanofeature size dictates stem cell differentiation
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00683959v1
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