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Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

dc.rights.licenseopenen_US
dc.contributor.authorFRETTS, A. M.
dc.contributor.authorIMAMURA, F.
dc.contributor.authorMARKLUND, M.
dc.contributor.authorMICHA, R.
dc.contributor.authorWU, J. H. Y.
dc.contributor.authorMURPHY, R. A.
dc.contributor.authorCHIEN, K. L.
dc.contributor.authorMCKNIGHT, B.
dc.contributor.authorTINTLE, N.
dc.contributor.authorFOROUHI, N. G.
dc.contributor.authorQURESHI, W. T.
dc.contributor.authorVIRTANEN, J. K.
dc.contributor.authorWONG, K.
dc.contributor.authorWOOD, A. C.
dc.contributor.authorLANKINEN, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAJAOBELINA, Kalina
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorDJOUSSE, L.
dc.contributor.authorHARRIS, B.
dc.contributor.authorWAREHAM, N. J.
dc.contributor.authorSTEFFEN, L. M.
dc.contributor.authorLAAKSO, M.
dc.contributor.authorVEENSTRA, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorBROUWER, I. A.
dc.contributor.authorYU, C. I.
dc.contributor.authorKOULMAN, A.
dc.contributor.authorSTEFFEN, B. T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorSOTOODEHNIA, N.
dc.contributor.authorSISCOVICK, D.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorWAGENKNECHT, L.
dc.contributor.authorVOUTILAINEN, S.
dc.contributor.authorTSAI, M. Y.
dc.contributor.authorUUSITUPA, M.
dc.contributor.authorKALSBEEK, A.
dc.contributor.authorBERR, C.
dc.contributor.authorMOZAFFARIAN, D.
dc.contributor.authorLEMAITRE, R. N.
dc.date.accessioned2020-06-10T15:24:48Z
dc.date.available2020-06-10T15:24:48Z
dc.date.issued2019-04-01
dc.identifier.issn0002-9165en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7873
dc.description.abstractEnBACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enAssociations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies
dc.title.alternativeAm J Clin Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ajcn/nqz005en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30982858en_US
bordeaux.journalAm J Clin Nutren_US
bordeaux.page1216-1223en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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