A reappraisal of the role of fever in the occurrence of neurological sequelae following lithium intoxication: a systematic review
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | VERDOUX, Helene
IDREF: 115951903 | |
| dc.contributor.author | DEBRUYNE, Anne-Laure | |
| dc.contributor.author | QUEUILLE, Emmanuelle | |
| dc.contributor.author | DE LEON, Jose | |
| dc.date.accessioned | 2021-05-17T07:36:04Z | |
| dc.date.available | 2021-05-17T07:36:04Z | |
| dc.date.issued | 2021-03-31 | |
| dc.identifier.issn | 1744-764X (Electronic) 1474-0338 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78579 | |
| dc.description.abstractEn | We aimed to review cases of Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) characterized by neurological sequelae following acute lithium toxicity and to explore whether cerebellar sequelae are more frequent in cases presenting with fever and/or infection.Areas covered: Case reports were identified from: (i) 6 reviews published up to 2005; (ii) MEDLINE, Web of Sciences, Cochrane Library and PsycINFO search.Expert opinion: We identified 123 SILENT cases published from 1965 to 2019, in which cerebellar sequelae were observed in an overwhelming proportion (79%). SILENT may occur at any time during lithium treatment. This complication is most frequently observed during routine lithium treatment, with fewer than 10% of cases occurring after accidental or intentional overdoses. SILENT may occur even when lithium plasma levels are within the therapeutic range: 63% of cases had lithium plasma level <2.5 mEq/l (low/mild toxicity). Fever and/or infection were reported in nearly half of the patients (48%). The likelihood of presenting with cerebellar vs. other neurological sequelae was independently increased by elevated plasma lithium level (≥ 2.5 mEq/l) and by a history of fever and/or infection. Lithium users should be warned of the need to consult in case of fever to adjust their lithium dosage. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Lithium | |
| dc.subject.en | Adverse drug reaction | |
| dc.subject.en | Neurotoxicity | |
| dc.subject.en | Fever | |
| dc.subject.en | Infection | |
| dc.title.en | A reappraisal of the role of fever in the occurrence of neurological sequelae following lithium intoxication: a systematic review | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1080/14740338.2021.1912011 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33789560 | en_US |
| bordeaux.journal | Expert Opinion on Drug Safety | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03227182 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-05-17T07:36:08Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Expert%20Opinion%20on%20Drug%20Safety&rft.date=2021-03-31&rft.eissn=1744-764X%20(Electronic)%201474-0338%20(Linking)&rft.issn=1744-764X%20(Electronic)%201474-0338%20(Linking)&rft.au=VERDOUX,%20Helene&DEBRUYNE,%20Anne-Laure&QUEUILLE,%20Emmanuelle&DE%20LEON,%20Jose&rft.genre=article |
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