Management of Biliary Atresia in France 1986 to 2015: Long-term Results
| dc.rights.license | open | en_US |
| dc.contributor.author | FANNA, M. | |
| dc.contributor.author | MASSON, G. | |
| dc.contributor.author | CAPITO, C. | |
| dc.contributor.author | GIRARD, M. | |
| dc.contributor.author | GUERIN, F. | |
| dc.contributor.author | HERMEZIU, B. | |
| dc.contributor.author | LACHAUX, A. | |
| dc.contributor.author | ROQUELAURE, B. | |
| dc.contributor.author | GOTTRAND, F. | |
| dc.contributor.author | BROUE, P. | |
| dc.contributor.author | DABADIE, A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LAMIREAU, Thierry | |
| dc.contributor.author | JACQUEMIN, E. | |
| dc.contributor.author | CHARDOT, C. | |
| dc.date.accessioned | 2020-06-08T11:57:46Z | |
| dc.date.available | 2020-06-08T11:57:46Z | |
| dc.date.issued | 2019-10 | |
| dc.identifier.issn | 1536-4801 (Electronic) 0277-2116 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7812 | |
| dc.description.abstractEn | OBJECTIVES: This study analyses the prognosis of Biliary Atresia (BA) in France since 1986, when both Kasai operation (KOp) and Liver Transplantation (LT) became widely available. METHODS: The charts of all patients diagnosed with BA born between 1986 and 2015 and living in France were reviewed. RESULTS: 1428 patients were included; 1340 (94%) underwent KOp. Total clearance of jaundice (total bilirubin </=20 mumol/l) was documented in 516 patients (39%). Age at KOp (median 59 days, range 6-199) was stable over time. Survival with Native Liver (SNL) after KOp was 41%, 35%, 26% and 22% at 5, 10, 20 and 30 years, stable in the 4 cohorts. 25-year SNL was 38%, 27%, 22%, 19% in patients operated in the 1, 2, 3 month of life or later, respectively (p = 0.0001). Center caseloads had a significant impact on results in the 1986-96 cohort only.16%, 7%, 7%, 8% of patients died without LT in the 4 cohorts (p = 0.0001).753 patients (55%) underwent LT. Patient survival after LT was 79% at 28 years. 5-year patient survival after LT was 76%, 91%, 88%, and 92% in cohorts 1 to 4, respectively (p < 0.0001),Actual BA patient survival (from diagnosis) was 81%. 5-year BA patient survival was 72%, 88%, 87%, 87% in cohorts 1986-96, 1997-2002, 2003-09, 2010-15, respectively (p < 0.0001). CONCLUSIONS: In France, 87% of BA patients survive nowadays and 22% reach the age of 30 years without transplantation. Improvement of BA prognosis is mainly due to reduced mortality before LT and better outcomes after LT. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | LEHA | |
| dc.title.en | Management of Biliary Atresia in France 1986 to 2015: Long-term Results | |
| dc.title.alternative | J Pediatr Gastroenterol Nutr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/mpg.0000000000002446 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31335841 | en_US |
| bordeaux.journal | J Pediatr Gastroenterol Nutr | en_US |
| bordeaux.page | 416-424 | en_US |
| bordeaux.volume | 69 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=J%20Pediatr%20Gastroenterol%20Nutr&rft.date=2019-10&rft.volume=69&rft.issue=4&rft.spage=416-424&rft.epage=416-424&rft.eissn=1536-4801%20(Electronic)%200277-2116%20(Linking)&rft.issn=1536-4801%20(Electronic)%200277-2116%20(Linking)&rft.au=FANNA,%20M.&MASSON,%20G.&CAPITO,%20C.&GIRARD,%20M.&GUERIN,%20F.&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||