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Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment.

dc.contributor.authorGÉRARD, Alain
hal.structure.identifierInstitut de Recherche en Médecine Générale
dc.contributor.authorLIARD, François
dc.contributor.authorCROCHARD, Anne
hal.structure.identifierLundbeck-France
dc.contributor.authorGONI, Sylvia
hal.structure.identifierCentre Hospitalier Guillaume Régnier [CHGR]
dc.contributor.authorMILLET, Bruno
dc.date.accessioned2021-05-14T09:57:41Z
dc.date.available2021-05-14T09:57:41Z
dc.date.issued2011-11-30
dc.identifier.issn1176-6328
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77884
dc.description.abstractEnThe primary objective of this prospective observational study was to evaluate changes in self-reported disability in patients with anxiety or mood disorders 3 months after initiating antidepressant treatment. This study included 8396 patients consulting 2433 general practitioners in France for a major mood episode, generalized anxiety disorder, social anxiety disorder, panic disorder, or obsessive-compulsive disorder. Treatment was initiated with the antidepressant that the physician considered appropriate. Patients were evaluated with the Sheehan Disability Scale (SDS), Hospital Anxiety and Depression Scale, and Clinical Global Impression-Severity (CGI-S) at baseline and after 6 and 12 weeks. At 12 weeks, 6617 patients (78.8%) were evaluable. At inclusion, the mean SDS subscores were 6.5 ± 2.2 on the work/school activities dimension, 6.8 ± 1.9 on the social activities dimension, and 6.5 ± 2.0 on the family life dimension. At the 12-week follow-up visit, the mean change in score on these three dimensions was -3.9 ± 2.6, -4.2 ± 2.5, and -4.0 ± 2.5, respectively. At the 12-week follow-up visit, 90.0% of patients were responders (defined as patients whose SDS dimension scores decreased by at least one point) on the work/school SDS subscores; 92.8% were responders on the social life SDS subscores, and 91.1% were responders on family life/home responsibilities SDS subscores. Functional remission (defined as an SDS subscore of 0 at study end) rates were 18.0% for the work/school dimension, 16.8% for the social activities dimension, and 19.5% for the family life dimension. Using a cutoff of ≤2, remission rates were 56.8%, 55.0%, and 58.0%, respectively. Improvements in self-rated disability were correlated with improvements in symptoms measured with clinician-rated CGI-S. Patients consulting for anxiety or mood disorders report significant disability, which can be effectively reduced by antidepressant treatment.
dc.language.isoen
dc.publisherDove Medical Press
dc.title.enDisability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment.
dc.typeArticle de revue
dc.identifier.doi10.2147/NDT.S34132
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalNeuropsychiatric Disease and Treatment
bordeaux.page605-14
bordeaux.volume8
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-01133860
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01133860v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychiatric%20Disease%20and%20Treatment&rft.date=2011-11-30&rft.volume=8&rft.spage=605-14&rft.epage=605-14&rft.eissn=1176-6328&rft.issn=1176-6328&rft.au=G%C3%89RARD,%20Alain&LIARD,%20Fran%C3%A7ois&CROCHARD,%20Anne&GONI,%20Sylvia&MILLET,%20Bruno&rft.genre=article


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