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Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?

hal.structure.identifierCentre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM]
dc.contributor.authorCAROPPO, Paola
hal.structure.identifierLaboratoire d'Imagerie Biomédicale [Paris] [LIB]
dc.contributor.authorHABERT, Marie-Odile
hal.structure.identifierAlgorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
dc.contributor.authorDURRLEMAN, Stanley
hal.structure.identifierNeurosciences précliniques
dc.contributor.authorFUNKIEWIEZ, Aurélie
hal.structure.identifierLaboratoire d'Imagerie Fonctionnelle [LIF]
dc.contributor.authorPERLBARG, Vincent
hal.structure.identifierInstitut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]
dc.contributor.authorHAHN, Valérie
hal.structure.identifierTransferts, écoulements, fluides, énergétique [TREFLE]
dc.contributor.authorBERTIN, Hugo
hal.structure.identifierLaboratoire d'océanographie de Villefranche [LOV]
dc.contributor.authorGAUBERT, Malo
hal.structure.identifierAlgorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
dc.contributor.authorROUTIER, Alexandre
hal.structure.identifierGénétique du cancer et des maladies neuropsychiatriques [GMFC]
dc.contributor.authorHANNEQUIN, Didier
hal.structure.identifierTroubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
dc.contributor.authorDERAMECOURT, Vincent
hal.structure.identifierTroubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
dc.contributor.authorPASQUIER, Florence
hal.structure.identifierNeurologie et thérapeutique expérimentale
dc.contributor.authorRIVAUD-PECHOUX, Sophie
hal.structure.identifierService de neurologie [Nantes]
dc.contributor.authorVERCELLETTO, Martine
hal.structure.identifierInstitut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]
dc.contributor.authorEDOUART, Geoffrey
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorVALABREGUE, Romain
hal.structure.identifierInstitut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]
dc.contributor.authorLEJEUNE, Pascal
hal.structure.identifierInstitut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]
dc.contributor.authorDIDIC, Mira
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorCORVOL, Jean-Christophe
hal.structure.identifierLaboratoire d'Imagerie Biomédicale [Paris] [LIB]
dc.contributor.authorBENALI, Habib
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorLEHÉRICY, Stéphane
hal.structure.identifierInstitut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]
dc.contributor.authorDUBOIS, Bruno
hal.structure.identifierAlgorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
dc.contributor.authorCOLLIOT, Olivier
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorBRICE, Alexis
hal.structure.identifierCentre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM]
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorLE BER, Isabelle
dc.date.accessioned2021-05-14T09:54:47Z
dc.date.available2021-05-14T09:54:47Z
dc.date.issued2015-08
dc.identifier.issn1387-2877
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77645
dc.description.abstractEnThe preclinical stage of frontotemporal lobar degeneration (FTLD) is not well characterized. We conducted a brain metabolism (FDG-PET) and structural (cortical thickness) study to detect early changes in asymptomatic GRN mutation carriers (aGRN+) that were evaluated longitudinally over a 20-month period. At baseline, a left lateral temporal lobe hypometabolism was present in aGRN+ without any structural changes. Importantly, this is the first longitudinal study and, across time, the metabolism more rapidly decreased in aGRN+ in lateral temporal and frontal regions. The main structural change observed in the longitudinal study was a reduction of cortical thickness in the left lateral temporal lobe in carriers. A limit of this study is the relatively small sample (n = 16); nevertheless, it provides important results. First, it evidences that the pathological processes develop a long time before clinical onset, and that early neuroimaging changes might be detected approximately 20 years before the clinical onset of disease. Second, it suggests that metabolic changes are detectable before structural modifications and cognitive deficits. Third, both the baseline and longitudinal studies provide converging results implicating lateral temporal lobe as early involved in GRN disease. Finally, our study demonstrates that structural and metabolic changes could represent possible biomarkers to monitor the progression of disease in the presymptomatic stage toward clinical onset.
dc.language.isoen
dc.publisherIOS Press
dc.subject.enfrontotemporal lobar degeneration
dc.subject.enfrontotemporal dementia
dc.subject.endementia
dc.subject.enPET
dc.subject.enGRN
dc.subject.enpreclinical study
dc.subject.enlongitudinal
dc.subject.enCortical thickness
dc.subject.enpresymptomatic
dc.subject.enprogranulin
dc.title.enLateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?
dc.typeArticle de revue
dc.identifier.doi10.3233/JAD-150270
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie
bordeaux.journalJournal of Alzheimer's Disease
bordeaux.page751-9
bordeaux.volume47
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.issue3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-01220380
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01220380v1
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