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Reevaluation of the diametral compression test for tablets using the flattened disc geometry

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dc.relation.isnodouble4e09a89d-148a-4572-a5de-a38ae88a04ab*
dc.relation.isnodouble51eeb655-2108-4b42-90a9-e7acb6c7a44a*
dc.relation.isnodouble7fb6c54c-7ffb-4ef1-bf5d-06300ab6cf60*
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorGUERARD, Sandra
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorCROQUELOIS, Benjamin
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorKOPP, Jean-Benoit
IDREF: 17687335X
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorGIRARDOT, Jeremie
IDREF: 180810375
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDIARRA, Harona
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorBUSIGNIES, Virginie
IDREF: 07355247X
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
dc.date.accessioned2021-05-14T09:53:01Z
dc.date.available2021-05-14T09:53:01Z
dc.date.issued2016
dc.identifier.issn0378-5173
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77492
dc.description.abstractEnMechanical strength is an important critical quality attribute for tablets. It is classically measured, in the pharmaceutical field, using the diametral compression test. Nevertheless, due to small contact area between the tablet and the platens, some authors suggested that during the test, the failure could occur in tension away from the center which would invalidate the test and the calculation of the tensile strength.In this study, the flattened disc geometry was used as an alternative to avoid contact problems. The diametral compression on both flattened and standard geometries was first studied using finite element method (FEM) simulation. It was found that, for the flattened geometry, both maximum tensile strain and stress were located at the center of the tablet, which was not the case for the standard geometry. Experimental observations using digital image correlation (DIC) confirmed the numerical results. The experimental tensile strength obtained using both geometries were compared and it was found that the standard geometry always gave lower tensile strength than the flattened geometry. Finally, high-speed video capture of the test made it possible to detect that for the standard geometry the crack initiation was always away from the center of the tablet.
dc.language.isoen
dc.publisherElsevier
dc.subject.enCompression
dc.subject.enTensile strength
dc.subject.ennumerical simulation
dc.subject.enTablet
dc.subject.enDiametral compression
dc.title.enReevaluation of the diametral compression test for tablets using the flattened disc geometry
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ijpharm.2016.09.088
dc.subject.halSciences de l'ingénieur [physics]/Mécanique [physics.med-ph]/Mécanique des matériaux [physics.class-ph]
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
bordeaux.journalInternational Journal of Pharmaceutics
bordeaux.page669-677
bordeaux.volume513
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.issue1-2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-01378705
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01378705v1
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