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GPs' management of polypharmacy and therapeutic dilemma in patients with multimorbidity: a cross-sectional survey of GPs in France

dc.rights.licenseopenen_US
dc.contributor.authorCARRIER, H.
dc.contributor.authorZAYTSEVA, A.
dc.contributor.authorBOCQUIER, A.
dc.contributor.authorVILLANI, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDOUX, Helene
dc.contributor.authorFORTIN, M.
dc.contributor.authorVERGER, P.
dc.date.accessioned2020-06-03T14:49:06Z
dc.date.available2020-06-03T14:49:06Z
dc.date.issued2019
dc.identifier.issn1478-5242 (Electronic) 0960-1643 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7732
dc.description.abstractEnBACKGROUND: GPs are confronted with therapeutic dilemmas in treating patients with multimorbidity and/or polypharmacy when unfavourable medication risk-benefit ratios (RBRs) conflict with patients' demands. AIM: To understand GPs' attitudes about prescribing and/or deprescribing medicines for patients with multimorbidity and/or polypharmacy, and factors associated with their decisions. DESIGN AND SETTING: Cross-sectional survey in 2016 among a national panel of 1266 randomly selected GPs in private practice in France. METHOD: GPs' opinions and attitudes were explored using a standardised questionnaire including a case vignette about a female treated for multiple somatic diseases, sleeping disorders, and chronic pain. Participants were randomly assigned one of eight versions of this case vignette, varying by patient age, socioprofessional status, and stroke history. Backward selection was used to identify factors associated with GPs' decisions about drugs they considered inappropriate. RESULTS: Nearly all (91.4%) responders felt comfortable or fairly comfortable deprescribing inappropriate medications, but only 34.7% decided to do so often or very often. In the clinical vignette, most GPs chose to discontinue symptomatic medications (for example, benzodiazepine, paracetamol/tramadol) because of unfavourable RBRs. When patients asked for ketoprofen for persistent sciatica, 94.1% considered this prescription risky, but 25.6% would prescribe it. They were less likely to prescribe it to older patients (adjusted odds ratio [AOR] 0.48, 95% confidence interval [CI] = 0.36 to 0.63), or those with a stroke history (AOR 0.55, 95% CI = 0.42 to 0.72). CONCLUSION: In therapeutic dilemmas, some GPs choose to prioritise patients' requests over iatrogenic risks. GPs need pragmatic implementation tools for handling therapeutic dilemmas, and to improve their skills in medication management and patient engagement in such situations.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.title.enGPs' management of polypharmacy and therapeutic dilemma in patients with multimorbidity: a cross-sectional survey of GPs in France
dc.title.alternativeBr J Gen Practen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3399/bjgp19X701801en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30803978en_US
bordeaux.journalThe British journal of general practiceen_US
bordeaux.pagee270-e278en_US
bordeaux.volume69en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue681en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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