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Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals

dc.rights.licenseopenen_US
dc.contributor.authorCANIGLIA, E. C.
dc.contributor.authorROBINS, J. M.
dc.contributor.authorCAIN, L. E.
dc.contributor.authorSABIN, C.
dc.contributor.authorLOGAN, R.
dc.contributor.authorABGRALL, S.
dc.contributor.authorMUGAVERO, M. J.
dc.contributor.authorHERNANDEZ-DIAZ, S.
dc.contributor.authorMEYER, L.
dc.contributor.authorSENG, R.
dc.contributor.authorDROZD, D. R.
dc.contributor.authorSEAGE III, G. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE MAREC, Fabien
dc.contributor.authorMOORE, R. D.
dc.contributor.authorREISS, P.
dc.contributor.authorVAN SIGHEM, A.
dc.contributor.authorMATHEWS, W. C.
dc.contributor.authorJARRIN, I.
dc.contributor.authorALEJOS, B.
dc.contributor.authorDEEKS, S. G.
dc.contributor.authorMUGA, R.
dc.contributor.authorBOSWELL, S. L.
dc.contributor.authorFERRER, E.
dc.contributor.authorERON, J. J.
dc.contributor.authorGILL, J.
dc.contributor.authorPACHECO, A.
dc.contributor.authorGRINSZTEJN, B.
dc.contributor.authorNAPRAVNIK, S.
dc.contributor.authorJOSE, S.
dc.contributor.authorPHILLIPS, A.
dc.contributor.authorJUSTICE, A.
dc.contributor.authorTATE, J.
dc.contributor.authorBUCHER, H. C.
dc.contributor.authorEGGER, M.
dc.contributor.authorFURRER, H.
dc.contributor.authorMIRO, J. M.
dc.contributor.authorCASABONA, J.
dc.contributor.authorPORTER, K.
dc.contributor.authorTOULOUMI, G.
dc.contributor.authorCRANE, H.
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorSAAG, M.
dc.contributor.authorHERNAN, M. A.
dc.date.accessioned2020-06-03T13:40:49Z
dc.date.available2020-06-03T13:40:49Z
dc.date.issued2019
dc.identifier.issn1097-0258 (Electronic) 0277-6715 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7726
dc.description.abstractEnDecisions about when to start or switch a therapy often depend on the frequency with which individuals are monitored or tested. For example, the optimal time to switch antiretroviral therapy depends on the frequency with which HIV-positive individuals have HIV RNA measured. This paper describes an approach to use observational data for the comparison of joint monitoring and treatment strategies and applies the method to a clinically relevant question in HIV research: when can monitoring frequency be decreased and when should individuals switch from a first-line treatment regimen to a new regimen? We outline the target trial that would compare the dynamic strategies of interest and then describe how to emulate it using data from HIV-positive individuals included in the HIV-CAUSAL Collaboration and the Centers for AIDS Research Network of Integrated Clinical Systems. When, as in our example, few individuals follow the dynamic strategies of interest over long periods of follow-up, we describe how to leverage an additional assumption: no direct effect of monitoring on the outcome of interest. We compare our results with and without the "no direct effect" assumption. We found little differences on survival and AIDS-free survival between strategies where monitoring frequency was decreased at a CD4 threshold of 350 cells/mul compared with 500 cells/mul and where treatment was switched at an HIV-RNA threshold of 1000 copies/ml compared with 200 copies/ml. The "no direct effect" assumption resulted in efficiency improvements for the risk difference estimates ranging from an 7- to 53-fold increase in the effective sample size.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.title.enEmulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
dc.title.alternativeStat Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/sim.8120en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30883859en_US
bordeaux.journalStatistics in medicineen_US
bordeaux.page2428-2446en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue13en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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