Hepatitis B virus activity in untreated hepatitis B e antigen-negative human immunodeficiency virus-hepatitis B virus co-infected patients from sub-Saharan Africa
| dc.rights.license | open | en_US |
| dc.contributor.author | BOYD, A. | |
| dc.contributor.author | KOUAME, Menan Gerard | |
| dc.contributor.author | HOUGHTALING, L. | |
| dc.contributor.author | MOH, Desmorys Raoul | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GABILLARD, Delphine | |
| dc.contributor.author | MAYLIN, S. | |
| dc.contributor.author | CHEKARAOU, M. A. | |
| dc.contributor.author | DELAUGERRE, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ANGLARET, Xavier | |
| dc.contributor.author | EHOLIE, S. P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DANEL, Christine | |
| dc.contributor.author | ZOULIM, F. | |
| dc.contributor.author | LACOMBE, K. | |
| dc.date.accessioned | 2020-06-03T11:47:38Z | |
| dc.date.available | 2020-06-03T11:47:38Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0035-9203 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7718 | |
| dc.description.abstractEn | Background In human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients from sub-Saharan Africa with hepatitis B e antigen (HBeAg)-negative status, data are limited on the evolution of HBV activity when antiretroviral treatment (ART) is absent. Methods A total of 43 HBeAg-negative co-infected patients not indicated for ART (per concomitant World Health Organization recommendations) were followed during participation in a randomized controlled trial in Cote d'Ivoire. Chronic HBeAg-negative phases were classified at yearly visits and defined as infection' (HBV DNA <= 10 000 copies/mL and normal alanine aminotransferase [ALT]) or hepatitis' (HBV DNA >10 000 copies/mL and/or above normal ALT). Dispersion in HBV DNA and ALT levels during follow-up was assessed using interquartile range (IQR) regression. Results During a median 25 months (IQR 19-31), 17 (40%) patients consistently had infection', 5 (12%) consistently had hepatitis' and 21 (48%) fluctuated between phases. Wider dispersion in HBV DNA over time was associated with higher baseline HIV RNA (p=0.02) and higher baseline HBV DNA levels (p=0.008), while wider dispersion in ALT was associated with higher baseline HIV RNA (p<0.001), higher baseline ALT levels (p=0.02) and baseline hepatitis surface antigen >4.0 log(10) IU/mL (p=0.02). Conclusions HBV activity is common with HBeAg-negative status, whose variation is partly linked to HIV replication. Fluctuations in disease phase make it difficult to assess the risk of morbidity and mortality after ART initiation. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | IDLIC | |
| dc.title.en | Hepatitis B virus activity in untreated hepatitis B e antigen-negative human immunodeficiency virus-hepatitis B virus co-infected patients from sub-Saharan Africa | |
| dc.title.alternative | Transactions of the Royal Society of Tropical Medicine and Hygiene | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/trstmh/trz021 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | Transactions of The Royal Society of Tropical Medicine and Hygiene | en_US |
| bordeaux.page | 437-445 | en_US |
| bordeaux.volume | 113 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Recherches sur le Sida et les Hépatites Virales | en_US |
| hal.identifier | hal-03209864 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-27T13:04:59Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transactions%20of%20The%20Royal%20Society%20of%20Tropical%20Medicine%20and%20Hygiene&rft.date=2019&rft.volume=113&rft.issue=8&rft.spage=437-445&rft.epage=437-445&rft.eissn=0035-9203&rft.issn=0035-9203&rft.au=BOYD,%20A.&KOUAME,%20Menan%20Gerard&HOUGHTALING,%20L.&MOH,%20Desmorys%20Raoul&GABILLARD,%20Delphine&rft.genre=article |
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