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On the importance of substrate deformations for cell migration

hal.structure.identifierIngénierie Biomédicale et Mécanique des Matériaux [TIMC-IMAG-BioMMat]
dc.contributor.authorGAGNIEU, A
hal.structure.identifierIngénierie Biomédicale et Mécanique des Matériaux [TIMC-IMAG-BioMMat]
dc.contributor.authorCHAGNON, Grégory
hal.structure.identifierLaboratoire d'Etude des Microstructures et de Mécanique des Matériaux [LEM3]
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorCHEMISKY, Yves
IDREF: 143502301
dc.contributor.authorSTEPHANOU, A
dc.contributor.authorCHAUVIÈRE, A
dc.date.accessioned2021-05-14T09:37:13Z
dc.date.available2021-05-14T09:37:13Z
dc.date.issued2020
dc.date.conference2019-10-28
dc.identifier.issn1025-5842
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/76345
dc.description.abstractEnCell migration is essential for many biological processes such as tissue morphogenesis, wound healing or metastatic invasion in cancer. It is a complex and highly regulated phenomena closely guided and fine-tuned by both chemical and mechanical cues. Whereas chemoattraction has been extensively studied, the mechanical influence remains to be fully elucidated. Although cell sensitivity to the substrate rigidity is known under the term durotaxis [Marzban et al.2018] and substrate anisotropy is known to influence cellular organization [Checa et al. 2015] much less is known about cell sensitivity to environmental stresses and strains. This paper proposes to specifically focus on the cell sensitivity to substrate deformations during migration. Those are assumed to play a role in longrange cell-cell interactions [Han et al. 2018] by which a cell deforms the substrate [Tanimoto et al. 2014] and influences the orientation of migration of other cells in its neighbourhood. This form of mechanotaxis (to which we will refer as strain mechanosensing) could in particular explain how cells migrate towards each other to form vascular loops during angiogenesis whenchemotaxis is ruled out in a chemically saturated tissue.
dc.language.isoen
dc.publisherTaylor & Francis
dc.subject.enHybrid model
dc.subject.enCell migration
dc.subject.enMechanobiology
dc.title.enOn the importance of substrate deformations for cell migration
dc.typeArticle de revue
dc.subject.halPhysique [physics]/Mécanique [physics]/Mécanique des matériaux [physics.class-ph]
bordeaux.journalComputer Methods in Biomechanics and Biomedical Engineering
bordeaux.pageS334-S335
bordeaux.volume22 suppl 1
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.countryFR
bordeaux.title.proceeding44eme congres de la societe de biomecanique,
bordeaux.conference.cityPoitiers
bordeaux.peerReviewedoui
hal.identifierhal-02425956
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02425956v1
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