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Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

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dc.relation.isnodouble7fb6c54c-7ffb-4ef1-bf5d-06300ab6cf60*
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
dc.date.accessioned2021-05-14T09:30:36Z
dc.date.available2021-05-14T09:30:36Z
dc.date.issued2020-11
dc.identifier.issn0378-5173
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/75825
dc.description.abstractEnElastic properties are of particular interest during the development of tablets especially for the definition of the formulation and of the process parameters. Impulse excitation, which is used in several industrial fields to determine elastic properties of materials, is presented in this article as a new fast and relatively cheap technology for the determination of elastic constants of pharmaceutical tablets. This technique is based on the detection of the natural resonance frequencies of solids. It was found in the present work that, for tablets obtained using different products under different compaction pressures, it was possible to detect clearly at least 3 resonance frequencies. Moreover, the shape of the resonance peaks obtained in the spectrum could be a sign of the viscoelastic nature of the tablet. With the two first resonance frequencies, it was possible, under the assumption of isotropy, to calculate Young's modulus and Poisson's ratio for each tablet using the methodology presented in the norm ASTM E1876-01. The values obtained were found independent of the tablet size as expected, and were consistent with those presented in the literature using other methodologies. Moreover, using FEM simulation, it was found that the difference between the experimental value of the third resonance frequency and the value obtained numerically was well correlated with the expected anisotropy of the tablet. Impulse excitation could thus be an interesting methodology to study tablet anisotropy.
dc.description.sponsorshipClivage en compression pharmaceutique - ANR-17-CE08-0015
dc.language.isoen
dc.publisherElsevier
dc.subject.enTablet
dc.subject.enCompression
dc.subject.enElasticity
dc.subject.enYoung's modulus
dc.subject.enPoisson's ratio
dc.subject.enViscoelasticity
dc.subject.enAnisotropy
dc.title.enApplicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ijpharm.2020.119892
dc.subject.halSciences de l'ingénieur [physics]
bordeaux.journalInternational Journal of Pharmaceutics
bordeaux.page1-6
bordeaux.volume590
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-03166879
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03166879v1
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