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Interplay of secondary and tertiary folding in abiotic foldamers

dc.rights.licenseopenen_US
dc.relation.isnodouble451af093-2ad8-441f-b0e7-a6362268456b*
dc.relation.isnodouble125ce0a6-a9d2-4301-8fa8-84079b31f3a2*
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMAZZIER, Daniela
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDE, Soumen
dc.contributor.authorWICHER, Barbara
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMAURIZOT, Victor
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHUC, Ivan
dc.date.accessioned2020-05-11T13:14:57Z
dc.date.available2020-05-11T13:14:57Z
dc.date.issued2019
dc.identifier.issn2041-6520en_US
dc.identifier.otherhttp://www.rsc.org/suppdata/c9/sc/c9sc01322a/c9sc01322a1.pdfen_US
dc.identifier.otherhttp://www.rsc.org/suppdata/c9/sc/c9sc01322a/c9sc01322a2.cifen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7518
dc.description.abstractEnThe first true abiotic tertiary folded structures, i.e. at the exclusion of any aliphatic amino acid, have recently been introduced under the form of aromatic oligoamide helix-turn-helix foldamers stabilized by hydrogen bonds in organic solvents. We present an investigation of the interplay of secondary and tertiary folding and of some cooperative effects in these systems. A solid phase synthesis approach to the preparation of these sequences was developed to facilitate systematic variation. Flexible pyridine-based units were introduced in various proportions in replacement of more rigid quinoline-based units. Conformational behaviour was assessed in solution by NMR, in the solid state by X-ray crystallography, and computationally through molecular dynamics simulations. Altogether, our results demonstrate that tertiary folding stabilizes otherwise flexible secondary structures, and that the disruption of tertiary folds upon adding polar solvents follows different mechanisms depending on whether secondary structures are inherently stable or not. These findings constitute a solid basis on which to further increase the size and complexity of abiotic folded structures and to eventually orchestrate folding dynamics and responsiveness.
dc.language.isoENen_US
dc.title.enInterplay of secondary and tertiary folding in abiotic foldamers
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/c9sc01322a
dc.subject.halChimie/Matériauxen_US
bordeaux.journalChemical Scienceen_US
bordeaux.page6984-6991en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.issue29en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03184033
hal.version1
hal.date.transferred2021-03-29T08:50:38Z
hal.exporttrue
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