Multi-type Galton-Watson Processes with Affinity-Dependent Selection Applied to Antibody Affinity Maturation
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BALELLI, Irene | |
| dc.contributor.author | MILISIC, V. | |
| dc.contributor.author | WAINRIB, G. | |
| dc.date.accessioned | 2020-05-11T08:45:32Z | |
| dc.date.available | 2020-05-11T08:45:32Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 1522-9602 (Electronic) 0092-8240 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7508 | |
| dc.description.abstractEn | We analyze the interactions between division, mutation and selection in a simplified evolutionary model, assuming that the population observed can be classified into fitness levels. The construction of our mathematical framework is motivated by the modeling of antibody affinity maturation of B-cells in germinal centers during an immune response. This is a key process in adaptive immunity leading to the production of high-affinity antibodies against a presented antigen. Our aim is to understand how the different biological parameters affect the system's functionality. We identify the existence of an optimal value of the selection rate, able to maximize the number of selected B-cells for a given generation. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | SISTM | |
| dc.title.en | Multi-type Galton-Watson Processes with Affinity-Dependent Selection Applied to Antibody Affinity Maturation | |
| dc.title.alternative | Bull Math Biol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s11538-018-00548-y | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30535847 | en_US |
| bordeaux.journal | Bulletin of Mathematical Biology | en_US |
| bordeaux.page | 830-868 | en_US |
| bordeaux.volume | 81 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SISTM_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
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