Association of vitamin d with mild cognitive impairment and alzheimer's dementia in older mexican adults
| dc.rights.license | open | en_US |
| dc.contributor.author | AGUILAR-NAVARRO, S. G. | |
| dc.contributor.author | MIMENZA-ALVARADO, A. J. | |
| dc.contributor.author | JIMENEZ-CASTILLO, G. A. | |
| dc.contributor.author | BRACHO-VELA, L. A. | |
| dc.contributor.author | YEVERINO-CASTRO, S. G. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AVILA-FUNES, José A. | |
| dc.date.accessioned | 2020-05-06T13:21:02Z | |
| dc.date.available | 2020-05-06T13:21:02Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0034-8376 (Print) 0034-8376 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7489 | |
| dc.description.abstractEn | Background: It has been proposed that Vitamin D helps reduce the accumulation of cerebral beta-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer's dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (> 65 years). Methods: Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels: sufficiency (> 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (</= 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed. Results: We evaluated 208 patients. Mean age was 79 +/- 1 year, 65% (n = 136) were female; and mean educational level was 6.7 +/- 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p < 0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p < 0.001) and AD (HR 41.7 [5.76-301]; p < 0.001) after adjusting for confounders. Conclusions: Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Association of vitamin d with mild cognitive impairment and alzheimer's dementia in older mexican adults | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.24875/ric.19003079 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31823966 | en_US |
| bordeaux.journal | Revista de Investigacion Clinica | en_US |
| bordeaux.page | 381-386 | en_US |
| bordeaux.volume | 71 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03211462 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-28T15:11:32Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Revista%20de%20Investigacion%20Clinica&rft.date=2019&rft.volume=71&rft.issue=6&rft.spage=381-386&rft.epage=381-386&rft.eissn=0034-8376%20(Print)%200034-8376&rft.issn=0034-8376%20(Print)%200034-8376&rft.au=AGUILAR-NAVARRO,%20S.%20G.&MIMENZA-ALVARADO,%20A.%20J.&JIMENEZ-CASTILLO,%20G.%20A.&BRACHO-VELA,%20L.%20A.&YEVERINO-CASTRO,%20S.%20G.&rft.genre=article |
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