PIP2 Phospholipid-Induced Aggregation of Tau Filaments Probed by Tip-Enhanced Raman Spectroscopy
| dc.rights.license | open | en_US |
| dc.relation.isnodouble | dee058ed-fdeb-4b9b-8e81-645d067921d4 | * |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | TALAGA, David | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | SMERALDA, Willy | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | LESCOS, Laurie | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | HUNEL, Julien | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LEPEJOVA-CAUDY, Nad'a | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CULLIN, Christophe
ORCID: 0000-0003-4110-4677 IDREF: 85920959 | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | BONHOMMEAU, Sebastien | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LECOMTE, Sophie | |
| dc.date.accessioned | 2020-04-08T09:35:55Z | |
| dc.date.available | 2020-04-08T09:35:55Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1433-7851 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/4163 | |
| dc.description.abstractEn | The morphology and secondary structure of peptide fibers formed by aggregation of tubulin-associated unit (Tau) fragments (K18), in the presence of the inner cytoplasmic membrane phosphatidylinositol component (PIP2 ) or heparin sodium (HS) as cofactors, are determined with nanoscale (<10 nm) spatial resolution. By means of tip-enhanced Raman spectroscopy (TERS), the inclusion of PIP2 lipids in fibers is determined based on the observation of specific C=O ester vibration modes. Moreover, analysis of amide I and amide III bands suggests that the parallel beta-sheet secondary structure content is lower and the random coil content is higher for fibers grown from the PIP2 cofactor instead of HS. These observations highlight the occurrence of some local structural differences between these fibers. This study constitutes the first nanoscale structural characterization of Tau/phospholipid aggregates, which are implicated in deleterious mechanisms on neural membranes in Alzheimer's disease. | |
| dc.language.iso | EN | en_US |
| dc.title.en | PIP2 Phospholipid-Induced Aggregation of Tau Filaments Probed by Tip-Enhanced Raman Spectroscopy | |
| dc.title.alternative | Angew.Chem.Int. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/anie.201809636 | |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Angewandte Chemie (International ed. in English) | en_US |
| bordeaux.page | 15738-15742 | en_US |
| bordeaux.volume | 57 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | |
| bordeaux.issue | 48 | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03184340 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-29T11:44:44Z | |
| hal.export | true | |
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